Now showing items 1-10 of 10
Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.
(PloS one, 2017-01)
Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide ...
Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.
(Arthritis research & therapy, 2018-04-18)
BACKGROUND:Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and ...
Elucidating the Molecular Composition of Cartilage by Proteomics.
(J Proteome Res, 2016-02-05)
Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining the zonal distribution of cartilage have extracted proteins ...
A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.
(BMC Bioinformatics, 2013-12-16)
BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ...
Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis.
(Arthritis Res Ther, 2011)
INTRODUCTION: Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic ...
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
(PLoS One, 2010-03-17)
BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, ...
Biomarkers and proteomic analysis of osteoarthritis.
(Matrix Biol, 2014-10)
Our friend and colleague, Dr. Dick Heinegård, contributed greatly to the understanding of joint tissue biochemistry, the discovery and validation of arthritis-related biomarkers and the establishment of methodology for proteomic ...
Xanthine oxidase injurious response in acute joint injury
(CLINICA CHIMICA ACTA, 2015-12-07)
Biomarkers and proteomic analysis of osteoarthritis
(MATRIX BIOLOGY, 2014-10)
In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.
(Arthritis Rheumatol, 2014-03)
OBJECTIVE: To investigate the relationship between NF-κB activity, cytokine levels, and pain sensitivities in a rodent model of osteoarthritis (OA). METHODS: OA was induced in transgenic NF-κB-luciferase reporter mice via ...