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Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data.
(Biogerontology, 2011-04)
Small sample size of genetic data is often a limiting factor for desirable accuracy
of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic
data containing information on survival or disease ...
Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
(Mech Ageing Dev, 2010-05)
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic
receptor (ADRB2) gene appears to be associated with a broad range of aging-associated
phenotypes, including cancers at different sites, ...
Inter-chromosomal level of genome organization and longevity-related phenotypes in humans.
(Age (Dordr), 2013-04)
Studies focusing on unraveling the genetic origin of health span in humans assume
that polygenic, aging-related phenotypes are inherited through Mendelian mechanisms
of inheritance of individual genes. We use the Framingham ...
The role of lipid-related genes, aging-related processes, and environment in healthspan.
(Aging Cell, 2013-04)
The inherent complexity of aging-related traits can temper progress in unraveling
the genetic origins of healthspan. We focus on two generations in the Framingham Heart
Study, the original (FHS) and offspring (FHSO) cohorts, ...
Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.
(Biogerontology, 2016-02)
Complex diseases are major contributors to human mortality in old age. Paradoxically,
many genetic variants that have been associated with increased risks of such diseases
are found in genomes of long-lived people, and do ...
Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.
(Aging Cell, 2011-06)
Progress in unraveling the genetic origins of healthy aging is tempered, in part,
by a lack of replication of effects, which is often considered a signature of false-positive
findings. We convincingly demonstrate that the ...
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.
(PLoS One, 2015)
Insights into genetic origin of diseases and related traits could substantially impact
strategies for improving human health. The results of genome-wide association studies
(GWAS) are often positioned as discoveries ...
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
(PLoS Genet, 2014-01)
Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven
uniqueness in humans and its prominent role in geriatrics and gerontology. We use
large samples of longitudinally followed ...