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The role of lipid-related genes, aging-related processes, and environment in healthspan.

Arbeev, Konstantin; Arbeeva, L; Culminskaya, IV; Kulminski, Alexander; Stallard, Eric; Ukraintseva, Svetlana; Yashin, Anatoli I (Aging Cell, 2013-04)

The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, ...

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

Arbeev, Konstantin; Arbeeva, L; Christensen, Kaare; Culminskaya, IV; Kulminski, Alexander; Province, MA; Schupf, N; ... (10 authors) (PLoS Genet, 2014-01)

Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ...