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Validation and Identification of Invasive Salmonella Serotypes in Sub-Saharan Africa by Multiplex Polymerase Chain Reaction.

Aaby, P; Adu-Sarkodie, Y; Al-Emran, HM; Ali, M; Bjerregaard-Andersen, M; Crump, John Andrew; Cruz Espinoza, LM; ... (36 authors) (Clin Infect Dis, 2016-03-15)

Salmonella enterica serovar Typhi and nontyphoidal Salmonella (NTS) cause the majority of bloodstream infections in sub-Saharan Africa; however, serotyping is rarely performed. We validated a multiplex polymerase chain reaction ...

A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Cunningham, Coleen; Hamilton, Carol; Kibiki, Gibson S; Lancaster, KE; ... (18 authors) (BMC Infect Dis, 2014-02-20)

BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ...

Epidemiology of Coxiella burnetii infection in Africa: a OneHealth systematic review.

Cleaveland, S; Crump, John Andrew; Halliday, JEB; Reddy, Elizabeth A; Rubach, MP; Vanderburg, Sky (PLoS Negl Trop Dis, 2014-04)

BACKGROUND: Q fever is a common cause of febrile illness and community-acquired pneumonia in resource-limited settings. Coxiella burnetii, the causative pathogen, is transmitted among varied host species, but the epidemiology ...

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design.

Bonsignori, Mattia; Chen, X; Crump, John Andrew; Haynes, Barton Ford; Hwang, K-K; Kapiga, SH; Kepler, TB; ... (17 authors) (J Virol, 2012-04)

Plasma from a small subset of subjects chronically infected with HIV-1 shows remarkable magnitude and breadth of neutralizing activity. From one of these individuals (CH0219), we isolated two broadly neutralizing antibodies ...

Prevalence of mycobacteremia among HIV-infected infants and children in northern Tanzania.

Afwamba, IA; Buchanan, AM; Clifton, DC; Crump, John Andrew; Cunningham, Coleen; Gray, KD; Msuya, LJ; ... (8 authors) (Pediatr Infect Dis J, 2013-07)

Mycobacterium tuberculosis is a common cause of bloodstream infections among HIV-infected adults in sub-Saharan Africa, and is associated with high morbidity and mortality. We found no cases of mycobacteremia among 93 ill, ...

Brucellosis in low-income and middle-income countries.

Rubach, MP; Halliday, JEB; Cleaveland, S; Crump, John Andrew (Curr Opin Infect Dis, 2013-10)

PURPOSE OF REVIEW: Human brucellosis is a neglected, underrecognized infection of widespread geographic distribution. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock ...

Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.

Bartlett, John A; Crump, John Andrew; Grossmann, H; Masenga, EJ; Mavura, DR; Minja, E (Int J Dermatol, 2015-01)

Abnormal skin findings are identified in over 90% of human immunodeficiency virus (HIV)-infected persons globally. A prospective cohort study of HIV-infected patients with skin complaints commencing antiretroviral therapy ...

Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa.

Aaby, P; Ahmed El Tayeb, M; Ali, M; Aseffa, A; Baker, S; Bjerregaard-Andersen, M; Breiman, RF; ... (45 authors) (Clin Infect Dis, 2015-11-01)

BACKGROUND: The clinical diagnosis of bacterial bloodstream infections (BSIs) in sub-Saharan Africa is routinely confused with malaria due to overlapping symptoms. The Typhoid Surveillance in Africa Program (TSAP) recruited ...

Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource setting.

Amos, B; Buchanan, AM; Crump, John Andrew; Cunningham, Coleen; Mtove, G; Nadjm, B; Reyburn, H; ... (8 authors) (J Clin Virol, 2012-11)

BACKGROUND: Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge. OBJECTIVES: To assess ...

Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.

Aga, E; Badal-Faesen, S; Bartlett, John A; Crump, John Andrew; Hosseinipour, MC; Katzenstein, DA; Klingman, KL; ... (13 authors) (Clin Infect Dis, 2015-05-15)

BACKGROUND: The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir (LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency virus (HIV) regimens in Africa and Asia. ...