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Predictors and outcomes of Mycobacterium tuberculosis bacteremia among patients with HIV and tuberculosis co-infection enrolled in the ACTG A5221 STRIDE study.

Crump, John Andrew; Grinsztejn, B; Ive, PD; Jentsch, U; Kendall, MA; Kumwenda, Johnstone J; Swindells, S; ... (8 authors) (BMC Infect Dis, 2015-01-13)

BACKGROUND: We evaluated predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial comparing ...

Validation and Identification of Invasive Salmonella Serotypes in Sub-Saharan Africa by Multiplex Polymerase Chain Reaction.

Aaby, P; Adu-Sarkodie, Y; Al-Emran, HM; Ali, M; Bjerregaard-Andersen, M; Crump, John Andrew; Cruz Espinoza, LM; ... (36 authors) (Clin Infect Dis, 2016-03-15)

Salmonella enterica serovar Typhi and nontyphoidal Salmonella (NTS) cause the majority of bloodstream infections in sub-Saharan Africa; however, serotyping is rarely performed. We validated a multiplex polymerase chain reaction ...

A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania.

Bartlett, John A; Chow, S-C; Crump, John Andrew; Cunningham, Coleen; Hamilton, Carol; Kibiki, Gibson S; Lancaster, KE; ... (18 authors) (BMC Infect Dis, 2014-02-20)

BACKGROUND: Routine tuberculosis culture remains unavailable in many high-burden areas, including Tanzania. This study sought to determine the impact of providing mycobacterial culture results over standard of care ...

Tb in a global health exchange program.

Barry, M; Crump, John Andrew; Decamp, M; Richardson, G; Rodriguez, J; Sugarman, Jeremy (J Gen Intern Med, 2012-01)

Histoplasmosis among hospitalized febrile patients in northern Tanzania.

Crump, John Andrew; Diefenthal, HC; Kinabo, GD; Kirsch, EJ; Lofgren, SM; Maro, Venance P; Morrissey, AB; ... (11 authors) (Trans R Soc Trop Med Hyg, 2012-08)

Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania. ...

Prevalence of mycobacteremia among HIV-infected infants and children in northern Tanzania.

Afwamba, IA; Buchanan, AM; Clifton, DC; Crump, John Andrew; Cunningham, Coleen; Gray, KD; Msuya, LJ; ... (8 authors) (Pediatr Infect Dis J, 2013-07)

Mycobacterium tuberculosis is a common cause of bloodstream infections among HIV-infected adults in sub-Saharan Africa, and is associated with high morbidity and mortality. We found no cases of mycobacteremia among 93 ill, ...

Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.

Bartlett, John A; Crump, John Andrew; Grossmann, H; Masenga, EJ; Mavura, DR; Minja, E (Int J Dermatol, 2015-01)

Abnormal skin findings are identified in over 90% of human immunodeficiency virus (HIV)-infected persons globally. A prospective cohort study of HIV-infected patients with skin complaints commencing antiretroviral therapy ...

Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa.

Aaby, P; Ahmed El Tayeb, M; Ali, M; Aseffa, A; Baker, S; Bjerregaard-Andersen, M; Breiman, RF; ... (45 authors) (Clin Infect Dis, 2015-11-01)

BACKGROUND: The clinical diagnosis of bacterial bloodstream infections (BSIs) in sub-Saharan Africa is routinely confused with malaria due to overlapping symptoms. The Typhoid Surveillance in Africa Program (TSAP) recruited ...

Utility of rapid antibody tests to exclude HIV-1 infection among infants and children aged <18 months in a low-resource setting.

Amos, B; Buchanan, AM; Crump, John Andrew; Cunningham, Coleen; Mtove, G; Nadjm, B; Reyburn, H; ... (8 authors) (J Clin Virol, 2012-11)

BACKGROUND: Excluding HIV infection among infants and young children in resource-poor settings where nucleic acid amplification tests (NAAT) are not routinely available remains a considerable challenge. OBJECTIVES: To assess ...

Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230.

Aga, E; Badal-Faesen, S; Bartlett, John A; Crump, John Andrew; Hosseinipour, MC; Katzenstein, DA; Klingman, KL; ... (13 authors) (Clin Infect Dis, 2015-05-15)

BACKGROUND: The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir (LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency virus (HIV) regimens in Africa and Asia. ...