Skip to main content
Duke University Libraries
Search 
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • Search
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • Search
    • Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Search

    Show Advanced FiltersHide Advanced Filters

    Filters

    Use filters to refine the search results.

    Now showing items 1-10 of 47

    • Sort Options:
    • Relevance
    • Title Asc
    • Title Desc
    • Issue Date Asc
    • Issue Date Desc
    • Results Per Page:
    • 5
    • 10
    • 20
    • 40
    • 60
    • 80
    • 100
    Thumbnail

    Heptahelical receptor signaling: beyond the G protein paradigm. 

    Hall, RA; Lefkowitz, Robert J; Premont, Richard Thomas (J Cell Biol, 1999-05-31)
    Thumbnail

    Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. 

    Cross, HR; Koch, Walter J; Lefkowitz, Robert J; Murphy, E; Steenbergen, C (Circ Res, 1999-11-26)
    Cardiac beta(2)-adrenergic receptor (beta(2)AR) overexpression is a potential contractile therapy for heart failure. Cardiac contractility was elevated in mice overexpressing beta(2)ARs (TG4s) with no adverse effects under ...
    Thumbnail

    Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 

    Hamilton, RA; Jones, LR; Lefkowitz, Robert J; Mao, L; Milano, Carmelo Alessio; Rockman, Howard A (J Clin Invest, 1996-04-01)
    To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation on relaxation and phospholamban regulation, we studied the physiological and biochemical alterations associated with overexpression of ...
    Thumbnail

    Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. 

    Dolber, Paul Christian; Glower, Donald D Jr; Hata, Jonathan Andrew; Koch, Walter J; Lefkowitz, Robert J; Maurice, JP; McDonald, Patricia H; ... (10 authors) (J Clin Invest, 1999-07)
    Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac function ...
    Thumbnail

    Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. 

    Allen, LF; Caron, MG; King, K; Lefkowitz, Robert J; Lomasney, JW; Lorenz, W; Regan, JW; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-07)
    Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human alpha 2AR by using the polymerase chain reaction with ...
    Thumbnail

    G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 

    Allen, LF; Caron, MG; Cotecchia, S; Lefkowitz, Robert J (Proc Natl Acad Sci U S A, 1991-12-15)
    The alpha 1B-adrenergic receptor (alpha 1B-ADR) is a member of the G-protein-coupled family of transmembrane receptors. When transfected into Rat-1 and NIH 3T3 fibroblasts, this receptor induces focus formation ...
    Thumbnail

    A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. 

    Codina, J; Lefkowitz, Robert J; Lohse, M; Pei, G; Samama, P; Wang, M (Proc Natl Acad Sci U S A, 1994-03-29)
    The beta 2-adrenergic receptor (beta 2AR) can be constitutively activated by mutations in the third intracellular loop. Whereas the wild-type receptor exists predominantly in an inactive conformation (R) in the absence of ...
    Thumbnail

    Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. 

    Inglese, J; Iñiguez-Lluhi, JA; Koch, Walter J; Lefkowitz, Robert J; Luttrell, LM; Touhara, K (Proc Natl Acad Sci U S A, 1994-04-26)
    The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. beta ARK activity is ...
    Thumbnail

    Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. 

    Diversé-Pierluissi, M; Drazner, Mark H; Dyer, SL; Freedman, NJ; Lefkowitz, Robert J; Oppermann, M; Peppel, Karsten C (Proc Natl Acad Sci U S A, 1996-07-23)
    Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization ...
    Thumbnail

    Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. 

    Akhter, SA; Glower, Donald D Jr; Koch, Walter J; Kypson, Alan P; Lefkowitz, Robert J; McDonald, Patricia H; Peppel, Karsten C; ... (8 authors) (Proc Natl Acad Sci U S A, 1997-10-28)
    Cardiovascular gene therapy is a novel approach to the treatment of diseases such as congestive heart failure (CHF). Gene transfer to the heart would allow for the replacement of defective or missing cellular proteins that ...
    • 1
    • 2
    • 3
    • 4
    • . . .
    • 5
     

     

    Browse

    All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

    My Account

    LoginRegister

    Discover

    Author
    Lefkowitz, Robert J (47)
    Koch, Walter J (17)Caron, MG (11)Rockman, Howard A (7)Iaccarino, Guido (5)Pitcher, JA (5)Premont, Richard Thomas (5)Akhter, SA (4)Allen, LF (4)Bond, RA (4)... View MoreDate Issued1999 (10)1996 (6)1998 (6)1990 (5)1994 (5)1997 (5)1993 (3)1995 (3)1991 (2)1992 (2)TypeJournal article (47)SubjectAnimals (39)GTP-Binding Proteins (23)Humans (23)Signal Transduction (18)beta-Adrenergic Receptor Kinases (17)Cyclic AMP-Dependent Protein Kinases (17)Receptors, Adrenergic, beta (15)Mice (14)Molecular Sequence Data (13)Amino Acid Sequence (12)... View MoreAffiliation of Duke Author(s)Basic Science Departments (45)Biochemistry (45)Chemistry (45)Clinical Science Departments (45)Duke (45)Duke Cancer Institute (45)Institutes and Centers (45)Medicine (45)Medicine, Cardiology (45)Pathology (45)... View More