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Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
(J Clin Invest, 1984-05)
Decreased activity of the guanine nucleotide regulatory protein (N) of the adenylate
cyclase system is present in cell membranes of some patients with pseudohypoparathyrodism
(PHP-Ia) whereas others have normal activity ...
Cloning of the cDNA for the human beta 1-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1987-11)
Screening of a human placenta lambda gt11 library has led to the isolation of the
cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the
human genomic clone termed G-21. This clone, which contains ...
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1988-10)
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides
corresponding to the partial amino acid sequence of the receptor protein purified
from DDT1MF-2 smooth muscle cells. The deduced ...
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
(Proc Natl Acad Sci U S A, 1986-09)
beta-Adrenergic receptor kinase (beta-AR kinase) is a cytosolic enzyme that phosphorylates
the beta-adrenergic receptor only when it is occupied by an agonist [Benovic, J. Strasser,
R. H., Caron, M. G. & Lefkowitz, R. J. ...
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
(Proc Natl Acad Sci U S A, 1987-12)
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin
kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is
occupied by stimulatory agonists. Since this kinase may ...
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
(Proc Natl Acad Sci U S A, 1989-07)
In addition to conveying cellular responses to an effector molecule, receptors are
often themselves regulated by their effectors. We have demonstrated that epinephrine
modulates both the rate of transcription of the beta ...
Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.
(Proc Natl Acad Sci U S A, 1985-09)
DDT1 MF-2 cells, which are derived from hamster vas deferens smooth muscle, contain
alpha 1-adrenergic receptors (54,800 +/- 2700 sites per cell) that are coupled to
stimulation of inositol phospholipid metabolism. Incubation ...
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
(Proc Natl Acad Sci U S A, 1987-01)
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor.
The deduced amino acid sequence (413 residues) is that of a protein containing seven
clusters of hydrophobic amino acids suggestive of ...
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
(Proc Natl Acad Sci U S A, 1988-09)
An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library
using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The
deduced amino acid sequence resembles the human platelet ...