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Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
(Proc Natl Acad Sci U S A, 1986-09)
beta-Adrenergic receptor kinase (beta-AR kinase) is a cytosolic enzyme that phosphorylates
the beta-adrenergic receptor only when it is occupied by an agonist [Benovic, J. Strasser,
R. H., Caron, M. G. & Lefkowitz, R. J. ...
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
(Proc Natl Acad Sci U S A, 1987-01)
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor.
The deduced amino acid sequence (413 residues) is that of a protein containing seven
clusters of hydrophobic amino acids suggestive of ...
cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.
(Proc Natl Acad Sci U S A, 1989-07)
In addition to conveying cellular responses to an effector molecule, receptors are
often themselves regulated by their effectors. We have demonstrated that epinephrine
modulates both the rate of transcription of the beta ...