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Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
(Proc Natl Acad Sci U S A, 1988-09)
An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library
using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The
deduced amino acid sequence resembles the human platelet ...
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
(J Clin Invest, 1984-05)
Decreased activity of the guanine nucleotide regulatory protein (N) of the adenylate
cyclase system is present in cell membranes of some patients with pseudohypoparathyrodism
(PHP-Ia) whereas others have normal activity ...
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
(Proc Natl Acad Sci U S A, 1987-01)
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor.
The deduced amino acid sequence (413 residues) is that of a protein containing seven
clusters of hydrophobic amino acids suggestive of ...
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
(Proc Natl Acad Sci U S A, 1987-12)
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin
kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is
occupied by stimulatory agonists. Since this kinase may ...
Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.
(Proc Natl Acad Sci U S A, 1988-12)
The beta 1- and beta 2-adrenergic receptors are two structurally related, but pharmacologically
distinguishable, receptor subtypes, both of which activate adenylyl cyclase in a catecholamine-dependent
manner through the ...
Cloning of the cDNA for the human beta 1-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1987-11)
Screening of a human placenta lambda gt11 library has led to the isolation of the
cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the
human genomic clone termed G-21. This clone, which contains ...
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.
(Proc Natl Acad Sci U S A, 1989-05)
Homologous (agonist-specific) desensitization of beta-adrenergic receptors (beta ARs)
is accompanied by and appears to require phosphorylation of the receptors. We have
recently described a novel protein kinase, beta AR ...