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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings.
(J Neurosci, 2015-03-18)
This study combines for the first time two major approaches to understanding the function
and structure of neural circuits: large-scale multielectrode recordings, and confocal
imaging of labeled neurons. To achieve this ...
A polyaxonal amacrine cell population in the primate retina.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-03)
Amacrine cells are the most diverse and least understood cell class in the retina.
Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal
processes. To explore their functional properties, ...
Dynamics of visual receptive fields in the macaque frontal eye field.
(J Neurophysiol, 2015-12)
Neuronal receptive fields (RFs) provide the foundation for understanding systems-level
sensory processing. In early visual areas, investigators have mapped RFs in detail
using stochastic stimuli and sophisticated analytical ...
Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
(Nat Neurosci, 2014-08)
Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating
nervous tissue, yet its mechanisms of effect are poorly understood. Here we report
new methods for studying the influence of TMS ...
Mapping nonlinear receptive field structure in primate retina at single cone resolution.
(eLife, 2015-10-30)
The function of a neural circuit is shaped by the computations performed by its interneurons,
which in many cases are not easily accessible to experimental investigation. Here,
we elucidate the transformation of visual signals ...
Neuronal correlates of metacognition in primate frontal cortex.
(Neuron, 2012-08-09)
Humans are metacognitive: they monitor and control their cognition. Our hypothesis
was that neuronal correlates of metacognition reside in the same brain areas responsible
for cognition, including frontal cortex. Recent ...
Division of labor in frontal eye field neurons during presaccadic remapping of visual receptive fields.
(J Neurophysiol, 2012-10)
Our percept of visual stability across saccadic eye movements may be mediated by presaccadic
remapping. Just before a saccade, neurons that remap become visually responsive at
a future field (FF), which anticipates the saccade ...
Activity of neurons in monkey globus pallidus during oculomotor behavior compared with that in substantia nigra pars reticulata.
(J Neurophysiol, 2010-04)
The basal ganglia are a subcortical assembly of nuclei involved in many aspects of
behavior. Three of the nuclei have high firing rates and inhibitory influences: the
substantia nigra pars reticulata (SNr), globus pallidus ...
Signal transformations from cerebral cortex to superior colliculus for the generation of saccades.
(Vision Res, 2001)
The ability of primates to make rapid and accurate saccadic eye movements for exploring
the natural world is based on a neuronal system in the brain that has been studied
extensively and is known to include multiple brain ...