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Heptahelical receptor signaling: beyond the G protein paradigm.
(J Cell Biol, 1999-05-31)
Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.
(Proc Natl Acad Sci U S A, 1992-07-01)
A number of lines of evidence suggest that cross-talk exists between the cellular
signal transduction pathways involving tyrosine phosphorylation catalyzed by members
of the pp60c-src kinase family and those mediated by ...
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.
(Proc Natl Acad Sci U S A, 1990-07)
Chronic exposure of various cell types to adrenergic agonists leads to a decrease
in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the
receptor away from the cell surface as well as a down-regulation ...
Chromosomal organization of adrenergic receptor genes.
(Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are
a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors
that mediate the physiological effects of the hormone ...
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
(J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied
beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating
adenylyl cyclase activity. Beta ARK-mediated receptor ...
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
(Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled
receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and
desensitization of G protein-coupled receptors. ...
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
(Proc Natl Acad Sci U S A, 1991-10-01)
Light-dependent deactivation of rhodopsin as well as homologous desensitization of
beta-adrenergic receptors involves receptor phosphorylation that is mediated by the
highly specific protein kinases rhodopsin kinase (RK) ...
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
(Proc Natl Acad Sci U S A, 1990-07)
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of
multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human
alpha 2AR by using the polymerase chain reaction with ...
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
(Proc Natl Acad Sci U S A, 1991-12-15)
The alpha 1B-adrenergic receptor (alpha 1B-ADR) is a member of the G-protein-coupled
family of transmembrane receptors. When transfected into Rat-1 and NIH 3T3 fibroblasts,
this receptor induces focus formation ...
An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.
(Proc Natl Acad Sci U S A, 1994-04-26)
Phosphorylation of GTP-binding-regulatory (G)-protein-coupled receptors by specific
G-protein-coupled receptor kinases (GRKs) is a major mechanism responsible for agonist-mediated
desensitization of signal transduction processes. ...