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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.
(Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis
in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity
influences the structural or symptomatic features of ...
Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species.
(Genome Biol, 2014)
BACKGROUND: Nearly one-quarter of all avian species is either threatened or nearly
threatened. Of these, 73 species are currently being rescued from going extinct in
wildlife sanctuaries. One of the previously most ...
Global view of the functional molecular organization of the avian cerebrum: mirror images and functional columns.
(J Comp Neurol, 2013-11)
Based on quantitative cluster analyses of 52 constitutively expressed or behaviorally
regulated genes in 23 brain regions, we present a global view of telencephalic organization
of birds. The patterns of constitutively expressed ...
Comparative genomics reveals insights into avian genome evolution and adaptation.
(Science, 2014-12-12)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance
across many research fields. We explored bird macroevolution using full genomes from
48 avian species representing all major extant clades. ...
Radioactive in situ hybridization for detecting diverse gene expression patterns in tissue.
(J Vis Exp, 2012-04-27)
Knowing the timing, level, cellular localization, and cell type that a gene is expressed
in contributes to our understanding of the function of the gene. Each of these features
can be accomplished with in situ hybridization ...
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells.
(J Clin Invest, 2015-02)
Satiety and other core physiological functions are modulated by sensory signals arising
from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors
called enteroendocrine cells. Despite being ...
Hybrid de novo genome assembly and centromere characterization of the gray mouse lemur (Microcebus murinus).
(BMC biology, 2017-11-16)
The de novo assembly of repeat-rich mammalian genomes using only high-throughput short
read sequencing data typically results in highly fragmented genome assemblies that
limit downstream applications. Here, we present an ...
Astrocytes refine cortical connectivity at dendritic spines.
(Elife, 2014-12-17)
During cortical synaptic development, thalamic axons must establish synaptic connections
despite the presence of the more abundant intracortical projections. How thalamocortical
synapses are formed and maintained in this ...
Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates.
(PLoS One, 2014)
The Hedgehog (Hh) gene family codes for a class of secreted proteins composed of two
active domains that act as signalling molecules during embryo development, namely
for the development of the nervous and skeletal systems ...
Phylogenomic analyses data of the avian phylogenomics project.
(Gigascience, 2015)
BACKGROUND: Determining the evolutionary relationships among the major lineages of
extant birds has been one of the biggest challenges in systematic biology. To address
this challenge, we assembled or collected the genomes ...