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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)
INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...
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Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. 

Bohórquez, Diego V; Calakos, Nicole; Erdmann, A; Kreger, AM; Liddle, Rodger Alan; Shahid, Rafiq; Wang, Fan; ... (8 authors) (J Clin Invest, 2015-02)
Satiety and other core physiological functions are modulated by sensory signals arising from the surface of the gut. Luminal nutrients and bacteria stimulate epithelial biosensors called enteroendocrine cells. Despite being ...
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Astrocytes refine cortical connectivity at dendritic spines. 

Risher, W Christopher; Patel, Sagar; Kim, Il Hwan; Uezu, Akiyoshi; Bhagat, Srishti; Wilton, Daniel K; Pilaz, Louis-Jan; ... (14 authors) (Elife, 2014-12-17)
During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ...
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Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain. 

Zhang, Yi; Chen, Yong; Liedtke, Wolfgang; Wang, Fan (Mol Pain, 2015-04-10)
BACKGROUND: Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies ...
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Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection. 

Bráz, João M; Wang, Fan; Basbaum, Allan I (PLoS One, 2015)
Although neuroanatomical tracing studies have defined the origin and targets of major projection neurons (PN) of the central nervous system (CNS), there is much less information about the circuits that influence these neurons. ...
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Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling. 

Arriaga, Gustavo; Macopson, Joshua J; Jarvis, Erich D (J Vis Exp, 2015-09-14)
Transsynaptic tracing has become a powerful tool used to analyze central efferents that regulate peripheral targets through multi-synaptic circuits. This approach has been most extensively used in the brain by utilizing ...
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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 

Gu, Bin; Huang, Yang Zhong; He, Xiao-Ping; Joshi, Rasesh B; Jang, Wonjo; McNamara, James O (Neuron, 2015-11-04)
The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing ...
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Chromosomal organization of adrenergic receptor genes. 

Yang-Feng, TL; Xue, FY; Zhong, WW; Cotecchia, S; Frielle, T; Caron, MG; Lefkowitz, RJ; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 

Jaber, M; Koch, WJ; Rockman, H; Smith, B; Bond, RA; Sulik, KK; Ross, J; ... (10 authors) (Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. ...
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Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

Bohn, Laura M; Gainetdinov, Raul R; Sotnikova, Tatyana D; Medvedev, Ivan O; Lefkowitz, Robert J; Dykstra, Linda A; Caron, Marc G (J Neurosci, 2003-11-12)
The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...
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AuthorChen, Yong (7)Jarvis, Erich D (7)Wang, Fan (7)Caron, Marc G (6)Lefkowitz, Robert J (5)Caron, MG (4)Lee, Suk Hee (4)Lefkowitz, RJ (4)Liedtke, Wolfgang (4)Setton, Lori A (4)... View MoreDate Issued2010 - 2018 (41)2000 - 2009 (9)1990 - 1999 (3)1986 - 1989 (1)TypeJournal article (54)Subject
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