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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.

Cao, L; Fermor, B; Griffin, TM; Guilak, Farshid; Huebner, JL; Kraus, Virginia Byers; Rodriguiz, Ramona M; ... (9 authors) (Arthritis Res Ther, 2010)

INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of ...

First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.

Jordan, J; Kepler, TB; Kraus, Virginia Byers; Renner, J; Stabler, Thomas (PLoS One, 2010-03-17)

BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, ...

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).

Catterall, JB; Flannery, CR; Kraus, Virginia Byers; Stabler, Thomas (Arthritis Res Ther, 2010)

INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand ...

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

Abramson, SB; Attur, M; Aziz, N; Bukowski, JF; Greenberg, J; Kornman, KS; Krasnokutsky, S; ... (11 authors) (Ann Rheum Dis, 2010-05)

BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify ...