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Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.

Kraus, Virginia; Reinke, Emily; Lattermann, Christian; Conley, Caitlin E-W; Johnson, Darren L; Huston, Laura J; Huebner, Janet L; ... (10 authors) (BioMed research international, 2018-01)

Background:The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and ...

A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.

AbouAssi, H; Bartlett, David Bruce; Bateman, LA; Connelly, MA; Huebner, JL; Huffman, Kim Marie; Kraus, Virginia Byers; ... (11 authors) (Arthritis Res Ther, 2016-04-12)

BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic ...

Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.

Byers, SS; Kraus, Virginia Byers; Stabler, Thomas; Zura, Robert Douglas (Arthritis Res Ther, 2009)

INTRODUCTION: Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues ...

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

Bain, James R; Huffman, Kim Marie; Kraus, Virginia Byers; Kraus, William Erle; Landerman, LR; Muehlbauer, Michael J; Newgard, Christopher Bang; ... (12 authors) (PLoS One, 2012)

OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or ...

Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.

Chakraborty, B; Chowbay, B; Haaland, B; Kraus, Virginia Byers; Leung, YY; Tan, MH; Thumboo, J; ... (8 authors) (Trials, 2015-04-30)

BACKGROUND: Despite the high prevalence and global impact of knee osteoarthritis (KOA), current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. We recently demonstrated ...

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

Abramson, SB; Attur, M; Aziz, N; Bukowski, JF; Greenberg, J; Kornman, KS; Krasnokutsky, S; ... (11 authors) (Ann Rheum Dis, 2010-05)

BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify ...