Search
Now showing items 1-10 of 58
Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)
Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may
alter their transcriptional activity. Thus, we determined the associations between
four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ...
Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
(Mol Carcinog, 2015-06)
CD133 is one of the most common stem cell markers, and functional single nucleotide
polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk
and patient survival. We hypothesized that potentially ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...
Integrated pathway and epistasis analysis reveals interactive effect of genetic variants at TERF1 and AFAP1L2 loci on melanoma risk.
(Int J Cancer, 2015-10-15)
Genome-wide association studies (GWASs) have characterized 13 loci associated with
melanoma, which only account for a small part of melanoma risk. To identify new genes
with too small an effect to be detected individually ...
The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
(PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs)
in its miRNA binding sites could modulate functions of the miRNA-target genes and
thus risk of cancers. In this study, we investigated ...
Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.
(BMC cancer, 2011-06-20)
Phospholipase C epsilon 1 (PLCE1) (an effector of Ras) belonging to the phospholipase
family plays crucial roles in carcinogenesis and progression of several cancers, including
squamous cell carcinoma of the head and neck ...
Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2012-01)
BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide
polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma.
In the present study, we validated ...
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
(BMC cancer, 2011-01)
BACKGROUND: The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1
(APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1
promoter -141T/G variant (rs1760944) has been reported ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...