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The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
(PloS one, 2013-01)
TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs)
in its miRNA binding sites could modulate functions of the miRNA-target genes and
thus risk of cancers. In this study, we investigated ...
Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: The mTOR gene regulates cell growth by controlling mRNA translation, ribosome
biogenesis, autophagy, and metabolism. Abnormally increased expression of mTOR was
associated with carcinogenesis, and its functional ...
Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites.
(Journal of cellular and molecular medicine, 2013-07)
Recently, several studies have investigated the association between a newly reported
rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer
risk, but generated inconsistent findings. The present ...
A pri-miR-218 variant and risk of cervical carcinoma in Chinese women.
(BMC cancer, 2013-01-15)
BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise
miRNA binding affinity and modify mRNA expression levels of the target genes, thus
leading to cancer susceptibility. However, few ...
TGFβ1 Polymorphisms Predict Distant Metastasis-Free Survival in Patients with Inoperable Non-Small-Cell Lung Cancer after Definitive Radiotherapy.
(PloS one, 2013-01)
Transforming growth factor (TGF) -β1 signaling is involved in cancer-cell metastasis.
We investigated whether single nucleotide polymorphisms (SNPs) at TGFβ1 were associated
with overall survival (OS) and distant metastasis-free ...
Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2013-01)
BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis
pathway and plays a crucial role in cancer development and progression. However, few
studies have evaluated associations between functional ...
MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.
(PloS one, 2013-01)
Both microRNAs and human papillomavirus (HPV) infection play an important role in
the development and progression of oral squamous cell carcinoma (OSCC). In addition,
microRNAs affect all facets of the immune/inflammation ...
Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma.
(Molecular cancer, 2013-07-19)
Tumor necrosis factor alpha (TNF-α) plays an important role in inflammation, immunity,
and defense against infection and clearance of human papillomavirus (HPV). Thus, genetic
variants may modulate individual susceptibility ...
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
(The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair
(NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients,
we evaluated whether genetic variants of NER genes ...
Joint effect of multiple common SNPs predicts melanoma susceptibility.
(PloS one, 2013-01)
Single genetic variants discovered so far have been only weakly associated with melanoma.
This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to
obtain a larger genetic effect and to improve the ...