Now showing items 1-3 of 3
Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.
(Arthritis Res Ther, 2009)
INTRODUCTION: Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues ...
Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.
BACKGROUND: Despite the high prevalence and global impact of knee osteoarthritis (KOA), current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. We recently demonstrated ...
Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
(Ann Rheum Dis, 2010-05)
BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify ...