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Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. 

Wang, Mengyun; Zhang, Ruoxin; He, Jing; Qiu, Lixin; Li, Jin; Wang, Yanong; Sun, Menghong; ... (15 authors) (PloS one, 2012-01)
BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma. In the present study, we validated ...
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On the interplay of telomeres, nevi and the risk of melanoma. 

Bodelon, Clara; Pfeiffer, Ruth M; Bollati, Valentina; Debbache, Julien; Calista, Donato; Ghiorzo, Paola; Fargnoli, Maria Concetta; ... (22 authors) (PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres ...
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RAD52 variants predict platinum resistance and prognosis of cervical cancer. 

Shi, Ting-Yan; Yang, Gong; Tu, Xiao-Yu; Yang, Jing-Min; Qian, Ji; Wu, Xiao-Hua; Zhou, Xiao-Yan; ... (9 authors) (PloS one, 2012-01)
RAD52 is an important but not well characterized homologous recombination repair gene that can bind to single-stranded DNA ends and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. ...
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Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck. 

Zhou, Ziyuan; Sturgis, Erich M; Liu, Zhensheng; Wang, Li-E; Wei, Qingyi; Li, Guojun (BMC cancer, 2012-05)
The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway. Human papillomavirus 16 (HPV16), by inducing p53 and pRb-E2F ...
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Association between single nucleotide polymorphisms in ERCC4 and risk of squamous cell carcinoma of the head and neck. 

Yu, Hongping; Liu, Zhensheng; Huang, Yu-Jing; Yin, Ming; Wang, Li-E; Wei, Qingyi (PloS one, 2012-01)
Excision repair cross-complementation group 4 gene (ERCC4/XPF) plays an important role in nucleotide excision repair and participates in removal of DNA interstrand cross-links and DNA double-strand breaks. Single nucleotide ...
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Correlation between base-excision repair gene polymorphisms and levels of in-vitro BPDE-induced DNA adducts in cultured peripheral blood lymphocytes. 

Yu, Hongping; Zhao, Hui; Wang, Li-E; Liu, Zhensheng; Li, Donghui; Wei, Qingyi (PloS one, 2012-01)
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individual's DNA repair phenotype that is associated with cancer risk. In ...
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Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients. 

Wu, Wenting; Li, Huan; Wang, Huibo; Zhao, Xueying; Gao, Zhiqiang; Qiao, Rong; Zhang, Wei; ... (13 authors) (PloS one, 2012-01)
PURPOSE: Xeroderma pigmentosum group D (XPD) codes for a DNA helicase involved in nucleotide excision repair that removes platinum-induced DNA damage. Genetic polymorphisms of XPD may affect DNA repair capacity and lead ...

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Author
Wei, Qingyi (7)
Liu, Zhensheng (3)Qian, Ji (3)Wang, Li-E (3)Wang, Jiucun (2)Yu, Hongping (2)Amos, Christopher (1)Bianchi-Scarra, Giovanna (1)Bodelon, Clara (1)Bollati, Valentina (1)... View MoreDate Issued
2012 (7)
TypeJournal article (7)SubjectAdult (7)
Aged (7)
Female (7)
Humans (7)
Middle Aged (7)
Polymorphism, Single Nucleotide (7)
Male (6)Genotype (5)Young Adult (4)Aged, 80 and over (3)... View MoreAffiliation of Duke Author(s)Basic Science Departments (7)Clinical Science Departments (7)Duke (7)Duke Cancer Institute (7)Institutes and Centers (7)
Medicine (7)
Medicine, Medical Oncology (7)Population Health Sciences (7)School of Medicine (7)Staff (3)
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