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Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations.
(Scientific reports, 2015-01)
Single nucleotide polymorphisms (SNPs) in the PI3K/PTEN/AKT/mTOR signaling pathway
may contribute to carcinogenesis. We genotyped five potentially functional PIK3R1
and mTOR SNPs in 1116 esophageal squamous cell cancer (ESCC) ...
Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)
Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may
alter their transcriptional activity. Thus, we determined the associations between
four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ...
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
(Tumour Biol, 2015-09)
The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of
apoptosis and the transformation and progression of malignant cells. Genetic variations
in KIF1B may contribute to risk of epithelial ovarian ...
Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.
(PloS one, 2012-01)
BACKGROUND: Recent genome-wide association studies (GWAS) have found a single nucleotide
polymorphism (SNP, rs2274223 A>G) in PLCE1 to be associated with risk of gastric adenocarcinoma.
In the present study, we validated ...
On the interplay of telomeres, nevi and the risk of melanoma.
(PloS one, 2012-01)
The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres
have been found to be associated with many cancers and with number of nevi, a known
risk factor for melanoma. However, shorter telomeres ...
RAD52 variants predict platinum resistance and prognosis of cervical cancer.
(PloS one, 2012-01)
RAD52 is an important but not well characterized homologous recombination repair gene
that can bind to single-stranded DNA ends and mediate the DNA-DNA interaction necessary
for the annealing of complementary DNA strands. ...
Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx.
(Oncotarget, 2016-05)
Functional polymorphisms of miRNAs may affect the function and target expression of
miRNAs, which can, in turn, affect the biological activity, etiology, and prognosis
of cancer. We hypothesized that four common polymorphisms ...
Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy.
(Oncotarget, 2016-06)
Common single nucleotide polymorphisms (SNPs) in miRNAs may affect miRNA functions
and their target expression and thus may affect biological activities and cancer etiology
as well as prognosis. Thus, we determined whether ...
The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
(BMC gastroenterology, 2009-10-16)
Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis
of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes
have been associated with risk and progression ...
Polymorphisms of nucleotide excision repair genes predict melanoma survival.
(The Journal of investigative dermatology, 2013-07)
Melanoma is the most highly malignant skin cancer, and nucleotide excision repair
(NER) is involved in melanoma susceptibility. In this analysis of 1,042 melanoma patients,
we evaluated whether genetic variants of NER genes ...