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A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.

Tao, Ye; Sturgis, Erich M; Huang, Zhigang; Sun, Yan; Dahlstrom, Kristina R; Wei, Qingyi; Li, Guojun (International journal of cancer, 2018-09)

TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with ...

Single-nucleotide polymorphisms of stemness genes predicted to regulate RNA splicing, microRNA and oncogenic signaling are associated with prostate cancer survival.

Freedman, Jennifer A; Wang, Yanru; Li, Xuechan; Liu, Hongliang; Moorman, Patricia G; George, Daniel J; Lee, Norman H; ... (10 authors) (Carcinogenesis, 2018-07)

Prostate cancer (PCa) is a clinically and molecularly heterogeneous disease, with variation in outcomes only partially predicted by grade and stage. Additional tools to distinguish indolent from aggressive disease are needed. ...

Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer.

Feng, Yun; Wang, Yanru; Liu, Hongliang; Liu, Zhensheng; Mills, Coleman; Owzar, Kouros; Xie, Jichun; ... (25 authors) (Molecular carcinogenesis, 2018-02)

The P38MAPK pathway participates in regulating cell cycle, inflammation, development, cell death, cell differentiation, and tumorigenesis. Genetic variants of some genes in the P38MAPK pathway are reportedly associated with ...

Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.

Duan, Bensong; Hu, Jiangfeng; Liu, Hongliang; Wang, Yanru; Li, Hongyu; Liu, Shun; Xie, Jichun; ... (12 authors) (International journal of cancer, 2018-04)

The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated ...

Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.

Wen, Juyi; Liu, Hongliang; Wang, Lili; Wang, Xiaomeng; Gu, Ning; Liu, Zhensheng; Xu, Ting; ... (11 authors) (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018-05)

INTRODUCTION:Autophagy not only plays an important role in the progression of cancer but is also involved in tissue inflammatory response. However, few published studies have investigated associations between functional ...