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The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.
(Sci Rep, 2012)
G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate
GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine
receptors are supersensitive in mice ...
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
(Proc Natl Acad Sci U S A, 1986-09)
beta-Adrenergic receptor kinase (beta-AR kinase) is a cytosolic enzyme that phosphorylates
the beta-adrenergic receptor only when it is occupied by an agonist [Benovic, J. Strasser,
R. H., Caron, M. G. & Lefkowitz, R. J. ...
Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.
(Proc Natl Acad Sci U S A, 1988-09)
An alpha 2-adrenergic receptor subtype has been cloned from a human kidney cDNA library
using the gene for the human platelet alpha 2-adrenergic receptor as a probe. The
deduced amino acid sequence resembles the human platelet ...
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
(J Clin Invest, 1984-05)
Decreased activity of the guanine nucleotide regulatory protein (N) of the adenylate
cyclase system is present in cell membranes of some patients with pseudohypoparathyrodism
(PHP-Ia) whereas others have normal activity ...
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
(Proc Natl Acad Sci U S A, 1987-01)
We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor.
The deduced amino acid sequence (413 residues) is that of a protein containing seven
clusters of hydrophobic amino acids suggestive of ...
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
(Proc Natl Acad Sci U S A, 1990-07)
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of
multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human
alpha 2AR by using the polymerase chain reaction with ...
G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.
(Proc Natl Acad Sci U S A, 1991-12-15)
The alpha 1B-adrenergic receptor (alpha 1B-ADR) is a member of the G-protein-coupled
family of transmembrane receptors. When transfected into Rat-1 and NIH 3T3 fibroblasts,
this receptor induces focus formation ...
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).
(Proc Natl Acad Sci U S A, 1987-12)
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin
kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is
occupied by stimulatory agonists. Since this kinase may ...
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
(Proc Natl Acad Sci U S A, 1988-10)
The cDNA for the Syrian hamster alpha 1-adrenergic receptor has been cloned with oligonucleotides
corresponding to the partial amino acid sequence of the receptor protein purified
from DDT1MF-2 smooth muscle cells. The deduced ...