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Adrenergic receptors. Models for regulation of signal transduction processes. 

Raymond, JR; Hnatowich, M; Lefkowitz, RJ; Caron, MG (Hypertension, 1990-02)
Adrenergic receptors are prototypic models for the study of the relations between structure and function of G protein-coupled receptors. Each receptor is encoded by a distinct gene. These receptors are integral membrane ...
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Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism. 

Heinsimer, JA; Davies, AO; Downs, RW; Levine, MA; Spiegel, AM; Drezner, MK; De Lean, A; ... (10 authors) (J Clin Invest, 1984-05)
Decreased activity of the guanine nucleotide regulatory protein (N) of the adenylate cyclase system is present in cell membranes of some patients with pseudohypoparathyrodism (PHP-Ia) whereas others have normal activity ...
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Cloning of the cDNA for the human beta 1-adrenergic receptor. 

Frielle, T; Collins, S; Daniel, KW; Caron, MG; Lefkowitz, RJ; Kobilka, BK (Proc Natl Acad Sci U S A, 1987-11)
Screening of a human placenta lambda gt11 library has led to the isolation of the cDNA for the human beta 1-adrenergic receptor (beta 1AR). Used as the probe was the human genomic clone termed G-21. This clone, which contains ...
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Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. 

Hausdorff, WP; Pitcher, JA; Luttrell, DK; Linder, ME; Kurose, H; Parsons, SJ; Caron, MG; ... (8 authors) (Proc Natl Acad Sci U S A, 1992-07-01)
A number of lines of evidence suggest that cross-talk exists between the cellular signal transduction pathways involving tyrosine phosphorylation catalyzed by members of the pp60c-src kinase family and those mediated by ...
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Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. 

Valiquette, M; Bonin, H; Hnatowich, M; Caron, MG; Lefkowitz, RJ; Bouvier, M (Proc Natl Acad Sci U S A, 1990-07)
Chronic exposure of various cell types to adrenergic agonists leads to a decrease in cell surface beta 2-adrenergic receptor (beta 2AR) number. Sequestration of the receptor away from the cell surface as well as a down-regulation ...
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Chromosomal organization of adrenergic receptor genes. 

Yang-Feng, TL; Xue, FY; Zhong, WW; Cotecchia, S; Frielle, T; Caron, MG; Lefkowitz, RJ; ... (8 authors) (Proc Natl Acad Sci U S A, 1990-02)
The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone ...
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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. 

Arriza, JL; Dawson, TM; Simerly, RB; Martin, LJ; Caron, MG; Snyder, SH; Lefkowitz, RJ (J Neurosci, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor ...
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Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 

Jaber, M; Koch, WJ; Rockman, H; Smith, B; Bond, RA; Sulik, KK; Ross, J; ... (10 authors) (Proc Natl Acad Sci U S A, 1996-11-12)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. ...
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Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. 

Sibley, DR; Benovic, JL; Caron, MG; Lefkowitz, RJ (Endocr Rev, 1988-02)
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 

Lorenz, W; Inglese, J; Palczewski, K; Onorato, JJ; Caron, MG; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1991-10-01)
Light-dependent deactivation of rhodopsin as well as homologous desensitization of beta-adrenergic receptors involves receptor phosphorylation that is mediated by the highly specific protein kinases rhodopsin kinase (RK) ...
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Author
Caron, MG (25)
Lefkowitz, RJ (25)Benovic, JL (5)Cotecchia, S (5)Frielle, T (4)Kobilka, BK (4)Yang-Feng, TL (4)Allen, LF (2)Bolanowski, MA (2)Bouvier, M (2)... View MoreDate Issued1990 - 1996 (11)1984 - 1989 (14)Type
Journal article (25)
SubjectAnimals (21)Receptors, Adrenergic, beta (16)Humans (12)Amino Acid Sequence (11)Molecular Sequence Data (11)Cricetinae (9)Cell Line (8)Base Sequence (7)Cell Membrane (7)GTP-Binding Proteins (7)... View MoreAffiliation of Duke Author(s)Basic Science Departments (25)Biochemistry (25)Cell Biology (25)Chemistry (25)
Clinical Science Departments (25)
Duke (25)Duke Cancer Institute (25)Duke Institute for Brain Sciences (25)Institutes and Centers (25)
Institutes and Provost's Academic Units (25)
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