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PhenX RISING: real world implementation and sharing of PhenX measures.
(BMC Med Genomics, 2014-03-20)
BACKGROUND: The purpose of this manuscript is to describe the PhenX RISING network
and the site experiences in the implementation of PhenX measures into ongoing population-based
genomic studies. METHODS: Eighty PhenX measures ...
Recovery and survival from aging-associated diseases.
(Exp Gerontol, 2013-08)
OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan
of the US elderly population may lead to erroneous conclusions when recovery/long-term
remission factors are underestimated. Using two ...
Does surgery improve outcomes for esophageal squamous cell carcinoma? An analysis using the surveillance epidemiology and end results registry from 1998 to 2008.
(J Am Coll Surg, 2012-11)
BACKGROUND: We examined survival associated with locally advanced esophageal squamous
cell cancer (SCC) to evaluate if treatment without surgery could be considered adequate.
STUDY DESIGN: Patients in the Surveillance, ...
Variability in the treatment of elderly patients with stage IIIA (N2) non-small-cell lung cancer.
(J Thorac Oncol, 2013-06)
INTRODUCTION: : We evaluated treatment patterns of elderly patients with stage IIIA
(N2) non-small-cell lung cancer (NSCLC). METHODS: : The use of surgery, chemotherapy,
and radiation for patients with stage IIIA (T1-T3N2M0) ...
Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.
(PLoS One, 2015)
BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting
that respiratory viral infection may induce biologic pathways that contribute to MI.
We tested the hypotheses that 1) a validated ...
Exploring the association between melanoma and glioma risks.
(Ann Epidemiol, 2014-06)
PURPOSE: Gliomas are one of the most fatal malignancies, with largely unknown etiology.
This study examines a possible connection between glioma and melanoma, which might
provide insight into gliomas' etiology. METHODS: ...
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
(J Thorac Cardiovasc Surg, 2014-04)
OBJECTIVE: Recently, the role of β-blockers (BBs) in reducing perioperative mortality
has been challenged. The conflicting results might have resulted from the extent of
BB metabolism by the cytochrome P-450 (CYP2D6) isoenzyme. ...
A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study.
(BMC Infect Dis, 2014-05-23)
BACKGROUND: Staphylococcus aureus bacteremia is a common infection associated with
significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide
active against Gram-positive pathogens, including ...
Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.
(Int J Dermatol, 2015-01)
Abnormal skin findings are identified in over 90% of human immunodeficiency virus
(HIV)-infected persons globally. A prospective cohort study of HIV-infected patients
with skin complaints commencing antiretroviral therapy ...
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)
A systems biology approach was used to comprehensively examine the impact of renal
disease and hemodialysis (HD) on patient response during critical illness. To achieve
this, we examined the metabolome, proteome, ...