Prostate cancer: an evolving paradigm.
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Since at least the early 1990s, stage and risk migration have been seen in patients with prostate cancer, likely corresponding to the institution of prostate specific antigen (PSA) screening in health systems. Preoperative risk factors, including PSA level and clinical stage, have decreased significantly. These improved prognostic variables have led to a larger portion of men being stratified with low-risk disease, as per the classification of D'Amico and associates. This, in turn, has corresponded with more favorable postoperative variables, including decreased extraprostatic tumor extension and prolonged biochemical-free recurrence rates. The advent of focal therapy is bolstered by findings of increased unilateral disease with decreased tumor volume. Increasingly, targeted or delayed therapies may be possible within the current era of lower risk disease.
Published Version (Please cite this version)10.1089/end.2009.0539
Publication InfoCaso, JR; Moul, JW; Mouraviev, V; Polascik, Thomas J; & Tsivian, M (2010). Prostate cancer: an evolving paradigm. J Endourol, 24(5). pp. 805-809. 10.1089/end.2009.0539. Retrieved from http://hdl.handle.net/10161/3242.
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Professor of Surgery
Prostate cancer imaging Focal therapy of prostate cancer Prostate cancer outcomes Kidney cancer outcomes Minimally invasive surgery Nerve sparing cryotherapy
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