Prostate cancer: an evolving paradigm.
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Since at least the early 1990s, stage and risk migration have been seen in patients with prostate cancer, likely corresponding to the institution of prostate specific antigen (PSA) screening in health systems. Preoperative risk factors, including PSA level and clinical stage, have decreased significantly. These improved prognostic variables have led to a larger portion of men being stratified with low-risk disease, as per the classification of D'Amico and associates. This, in turn, has corresponded with more favorable postoperative variables, including decreased extraprostatic tumor extension and prolonged biochemical-free recurrence rates. The advent of focal therapy is bolstered by findings of increased unilateral disease with decreased tumor volume. Increasingly, targeted or delayed therapies may be possible within the current era of lower risk disease.
Published Version (Please cite this version)10.1089/end.2009.0539
Publication InfoCaso, Jorge R; Mouraviev, Vladimir; Tsivian, Matvey; Polascik, Thomas J; & Moul, Judd W (2010). Prostate cancer: an evolving paradigm. J Endourol, 24(5). pp. 805-809. 10.1089/end.2009.0539. Retrieved from https://hdl.handle.net/10161/3242.
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James H. Semans, M.D. Distinguished Professor of Urologic Surgery, in the School of Medicine
Dr Judd Moul joined the Duke faculty in mid 2004 after a career in the US Army Medical Corps mainly at Walter Reed Army Medical Center. He is a retired colonel and a noted researcher and clinician in the area of prostate cancer and is a urologic oncologist. He served as the division chief of Duke Division of Urology from 2004 to 2011 and was named the James H Semans MD Professor of surgery in 2009 becoming Duke's first named endowed chair for urology. He was awarded the Gold Cystosco
Professor of Surgery
Prostate cancer imaging Focal therapy of prostate cancer Prostate cancer outcomes Kidney cancer outcomes Minimally invasive surgery Nerve sparing cryotherapy
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