Show simple item record Agar, M To, T Plummer, J Abernethy, A Currow, D
dc.coverage.spatial United States 2011-04-15T16:46:27Z 2010-06
dc.identifier.citation J Palliat Med, 2010, 13 (6), pp. 745 - 752
dc.description.abstract INTRODUCTION: Anti-cholinergic medications have been associated with increased risks of cognitive impairment, premature mortality and increased risk of hospitalisation. Anti-cholinergic load associated with medication increases as death approaches in those with advanced cancer, yet little is known about associated adverse outcomes in this setting. METHODS: A substudy of 112 participants in a randomised control trial who had cancer and an Australia modified Karnofsky Performance Scale (AKPS) score (AKPS) of 60 or above, explored survival and health service utilisation; with anti-cholinergic load calculated using the Clinician Rated Anti-cholinergic Scale (modified version) longitudinally to death. A standardised starting point for prospectively calculating survival was an AKPS of 60 or above. RESULTS: Baseline entry to the sub-study was a mean 62 +/- 81 days (median 37, range 1-588) days before death (survival), with mean of 4.8 (median 3, SD 4.18, range 1 - 24) study assessments in this time period. Participants spent 22% of time as an inpatient. There was no significant association between anti-cholinergic score and time spent as an inpatient (adjusted for survival time) (p = 0.94); or survival time. DISCUSSION: No association between anti-cholinergic load and survival or time spent as an inpatient was seen. Future studies need to include cognitively impaired populations where the risks of symptomatic deterioration may be more substantial.
dc.format.extent 745 - 752
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Palliat Med
dc.relation.isversionof 10.1089/jpm.2009.0365
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Australia
dc.subject Cholinergic Antagonists
dc.subject Dose-Response Relationship, Drug
dc.subject Female
dc.subject Health Services
dc.subject Humans
dc.subject Karnofsky Performance Status
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasm Staging
dc.subject Neoplasms
dc.subject Pilot Projects
dc.subject Survival Analysis
dc.title Anti-cholinergic load, health care utilization, and survival in people with advanced cancer: a pilot study.
dc.type Journal Article
dc.description.version Version of Record en_US 2010-6-0 en_US
duke.description.endpage 752 en_US
duke.description.issue 6 en_US
duke.description.startpage 745 en_US
duke.description.volume 13 en_US
dc.relation.journal Journal of palliative medicine en_US
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Medical Oncology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing - Secondary Group
pubs.publication-status Published
pubs.volume 13
dc.identifier.eissn 1557-7740

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