Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.
Repository Usage Stats
A recent quantum computing paper (G. S. Uhrig, Phys. Rev. Lett. 98, 100504 (2007)) analytically derived optimal pulse spacings for a multiple spin echo sequence designed to remove decoherence in a two-level system coupled to a bath. The spacings in what has been called a "Uhrig dynamic decoupling (UDD) sequence" differ dramatically from the conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo sequence. The UDD sequence was derived for a model that is unrelated to magnetic resonance, but was recently shown theoretically to be more general. Here we show that the UDD sequence has theoretical advantages for magnetic resonance imaging of structured materials such as tissue, where diffusion in compartmentalized and microstructured environments leads to fluctuating fields on a range of different time scales. We also show experimentally, both in excised tissue and in a live mouse tumor model, that optimal UDD sequences produce different T(2)-weighted contrast than do CPMG sequences with the same number of pulses and total delay, with substantial enhancements in most regions. This permits improved characterization of low-frequency spectral density functions in a wide range of applications.
Health Care Reform
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Published Version (Please cite this version)10.1063/1.3263196
Publication InfoJenista, ER; Stokes, AM; Branca, RT; & Warren, WS (2009). Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance. J Chem Phys, 131(20). pp. 204510. 10.1063/1.3263196. Retrieved from http://hdl.handle.net/10161/3315.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record