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Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.

dc.contributor.author Jenista, ER
dc.contributor.author Stokes, AM
dc.contributor.author Branca, RT
dc.contributor.author Warren, WS
dc.coverage.spatial United States
dc.date.accessioned 2011-04-15T16:46:39Z
dc.date.issued 2009-11-28
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/19947697
dc.identifier.uri http://hdl.handle.net/10161/3315
dc.description.abstract A recent quantum computing paper (G. S. Uhrig, Phys. Rev. Lett. 98, 100504 (2007)) analytically derived optimal pulse spacings for a multiple spin echo sequence designed to remove decoherence in a two-level system coupled to a bath. The spacings in what has been called a "Uhrig dynamic decoupling (UDD) sequence" differ dramatically from the conventional, equal pulse spacing of a Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo sequence. The UDD sequence was derived for a model that is unrelated to magnetic resonance, but was recently shown theoretically to be more general. Here we show that the UDD sequence has theoretical advantages for magnetic resonance imaging of structured materials such as tissue, where diffusion in compartmentalized and microstructured environments leads to fluctuating fields on a range of different time scales. We also show experimentally, both in excised tissue and in a live mouse tumor model, that optimal UDD sequences produce different T(2)-weighted contrast than do CPMG sequences with the same number of pulses and total delay, with substantial enhancements in most regions. This permits improved characterization of low-frequency spectral density functions in a wide range of applications.
dc.language eng
dc.language.iso en_US
dc.relation.ispartof J Chem Phys
dc.relation.isversionof 10.1063/1.3263196
dc.subject Animals
dc.subject Contrast Media
dc.subject Health Care Reform
dc.subject Magnetic Resonance Imaging
dc.subject Magnetic Resonance Spectroscopy
dc.subject Mice
dc.title Optimized, unequal pulse spacing in multiple echo sequences improves refocusing in magnetic resonance.
dc.type Journal article
dc.description.version Version of Record
duke.date.pubdate 2009-11-28
duke.description.issue 20
duke.description.volume 131
dc.relation.journal Journal of Chemical Physics
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/19947697
pubs.begin-page 204510
pubs.issue 20
pubs.organisational-group Chemistry
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Physics
pubs.organisational-group School of Medicine
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 131
dc.identifier.eissn 1089-7690


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