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Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering.

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Date
2010-04
Authors
Moutos, Franklin T
Guilak, Farshid
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Abstract
Articular cartilage possesses complex mechanical properties that provide healthy joints the ability to bear repeated loads and maintain smooth articulating surfaces over an entire lifetime. In this study, we utilized a fiber-reinforced composite scaffold designed to mimic the anisotropic, nonlinear, and viscoelastic biomechanical characteristics of native cartilage as the basis for developing functional tissue-engineered constructs. Three-dimensionally woven poly(epsilon-caprolactone) (PCL) scaffolds were encapsulated with a fibrin hydrogel, seeded with human adipose-derived stem cells, and cultured for 28 days in chondrogenic culture conditions. Biomechanical testing showed that PCL-based constructs exhibited baseline compressive and shear properties similar to those of native cartilage and maintained these properties throughout the culture period, while supporting the synthesis of a collagen-rich extracellular matrix. Further, constructs displayed an equilibrium coefficient of friction similar to that of native articular cartilage (mu(eq) approximately 0.1-0.3) over the prescribed culture period. Our findings show that three-dimensionally woven PCL-fibrin composite scaffolds can be produced with cartilage-like mechanical properties, and that these engineered properties can be maintained in culture while seeded stem cells regenerate a new, functional tissue construct.
Type
Journal article
Subject
Adult Stem Cells
Biocompatible Materials
Biomechanical Phenomena
Cartilage, Articular
Chondrocytes
Chondrogenesis
Collagen
Compressive Strength
Extracellular Matrix
Fibrin
Friction
Humans
Hydrogels
Materials Testing
Microscopy, Electron, Scanning
Polyesters
Regeneration
Shear Strength
Tensile Strength
Tissue Engineering
Tissue Scaffolds
Permalink
https://hdl.handle.net/10161/3355
Published Version (Please cite this version)
10.1089/ten.TEA.2009.0480
Publication Info
Moutos, Franklin T; & Guilak, Farshid (2010). Functional properties of cell-seeded three-dimensionally woven poly(epsilon-caprolactone) scaffolds for cartilage tissue engineering. Tissue Eng Part A, 16(4). pp. 1291-1301. 10.1089/ten.TEA.2009.0480. Retrieved from https://hdl.handle.net/10161/3355.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Farshid Guilak

Lazlo Ormandy Professor of Orthopaedic Surgery
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
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