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Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols.

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Date
2010-09
Authors
Price, CC
Wood, MF
Leonard, CM
Towler, S
Ward, J
Montijo, H
Kellison, I
Bowers, D
Monk, T
Newcomer, JC
Schmalfuss, I
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Abstract
Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination from the perirhinal cortex. From a sample of 39 nondemented older adults who completed volumetric image scans and verbal memory indices, we examined reliability and validity concerns for three ERC protocols with different lateral boundary guidelines (i.e., Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti et al., 1998). We used three novice raters to assess inter-rater reliability on a subset of scans (216 total ERCs), with the entire dataset measured by one rater with strong intra-rater reliability on each technique (234 total ERCs). We found moderate to strong inter-rater reliability for two techniques with consistent ERC lateral boundary endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the technique requiring consideration of collateral sulcal depth (Insausti). Left ERC and story memory associations were moderate and positive for two techniques designed to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique continuing to explain 10% of memory score variance after additionally controlling for depression symptom severity. Right ERC-story memory associations were nonexistent after excluding an outlier. Researchers are encouraged to consider challenges of rater training for ERC techniques and how lateral boundary endpoints may impact structure-function associations.
Type
Journal article
Subject
Aged
Brain Mapping
Entorhinal Cortex
Female
Functional Laterality
Geriatric Assessment
Humans
Magnetic Resonance Imaging
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
Reproducibility of Results
Permalink
https://hdl.handle.net/10161/3986
Published Version (Please cite this version)
10.1017/S135561771000072X
Publication Info
Price, CC; Wood, MF; Leonard, CM; Towler, S; Ward, J; Montijo, H; ... Schmalfuss, I (2010). Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols. J Int Neuropsychol Soc, 16(5). pp. 846-855. 10.1017/S135561771000072X. Retrieved from https://hdl.handle.net/10161/3986.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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