Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols.
Abstract
Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination
from the perirhinal cortex. From a sample of 39 nondemented older adults who completed
volumetric image scans and verbal memory indices, we examined reliability and validity
concerns for three ERC protocols with different lateral boundary guidelines (i.e.,
Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti
et al., 1998). We used three novice raters to assess inter-rater reliability on a
subset of scans (216 total ERCs), with the entire dataset measured by one rater with
strong intra-rater reliability on each technique (234 total ERCs). We found moderate
to strong inter-rater reliability for two techniques with consistent ERC lateral boundary
endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the
technique requiring consideration of collateral sulcal depth (Insausti). Left ERC
and story memory associations were moderate and positive for two techniques designed
to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique
continuing to explain 10% of memory score variance after additionally controlling
for depression symptom severity. Right ERC-story memory associations were nonexistent
after excluding an outlier. Researchers are encouraged to consider challenges of rater
training for ERC techniques and how lateral boundary endpoints may impact structure-function
associations.
Type
Journal articleSubject
AgedBrain Mapping
Entorhinal Cortex
Female
Functional Laterality
Geriatric Assessment
Humans
Magnetic Resonance Imaging
Male
Memory Disorders
Middle Aged
Neuropsychological Tests
Reproducibility of Results
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https://hdl.handle.net/10161/3986Published Version (Please cite this version)
10.1017/S135561771000072XPublication Info
Price, CC; Wood, MF; Leonard, CM; Towler, S; Ward, J; Montijo, H; ... Schmalfuss,
I (2010). Entorhinal cortex volume in older adults: reliability and validity considerations
for three published measurement protocols. J Int Neuropsychol Soc, 16(5). pp. 846-855. 10.1017/S135561771000072X. Retrieved from https://hdl.handle.net/10161/3986.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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