Show simple item record Price, CC Wood, MF Leonard, CM Towler, S Ward, J Montijo, H Kellison, I Bowers, D Monk, T Newcomer, JC Schmalfuss, I
dc.coverage.spatial England 2011-06-21T17:22:06Z 2010-09
dc.identifier S135561771000072X
dc.identifier.citation J Int Neuropsychol Soc, 2010, 16 (5), pp. 846 - 855
dc.description.abstract Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination from the perirhinal cortex. From a sample of 39 nondemented older adults who completed volumetric image scans and verbal memory indices, we examined reliability and validity concerns for three ERC protocols with different lateral boundary guidelines (i.e., Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti et al., 1998). We used three novice raters to assess inter-rater reliability on a subset of scans (216 total ERCs), with the entire dataset measured by one rater with strong intra-rater reliability on each technique (234 total ERCs). We found moderate to strong inter-rater reliability for two techniques with consistent ERC lateral boundary endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the technique requiring consideration of collateral sulcal depth (Insausti). Left ERC and story memory associations were moderate and positive for two techniques designed to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique continuing to explain 10% of memory score variance after additionally controlling for depression symptom severity. Right ERC-story memory associations were nonexistent after excluding an outlier. Researchers are encouraged to consider challenges of rater training for ERC techniques and how lateral boundary endpoints may impact structure-function associations.
dc.format.extent 846 - 855
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Int Neuropsychol Soc
dc.relation.isversionof 10.1017/S135561771000072X
dc.subject Aged
dc.subject Brain Mapping
dc.subject Entorhinal Cortex
dc.subject Female
dc.subject Functional Laterality
dc.subject Geriatric Assessment
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Memory Disorders
dc.subject Middle Aged
dc.subject Neuropsychological Tests
dc.subject Reproducibility of Results
dc.title Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-9-0 en_US
duke.description.endpage 855 en_US
duke.description.issue 5 en_US
duke.description.startpage 846 en_US
duke.description.volume 16 en_US
dc.relation.journal Journal of the International Neuropsychological Society en_US
pubs.issue 5
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Faculty
pubs.publication-status Published
pubs.volume 16
dc.identifier.eissn 1469-7661

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