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Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols.

dc.contributor.author Price, CC
dc.contributor.author Wood, MF
dc.contributor.author Leonard, CM
dc.contributor.author Towler, S
dc.contributor.author Ward, J
dc.contributor.author Montijo, H
dc.contributor.author Kellison, I
dc.contributor.author Bowers, D
dc.contributor.author Monk, T
dc.contributor.author Newcomer, JC
dc.contributor.author Schmalfuss, I
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:22:06Z
dc.date.issued 2010-09
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20937164
dc.identifier S135561771000072X
dc.identifier.uri https://hdl.handle.net/10161/3986
dc.description.abstract Measuring the entorhinal cortex (ERC) is challenging due to lateral border discrimination from the perirhinal cortex. From a sample of 39 nondemented older adults who completed volumetric image scans and verbal memory indices, we examined reliability and validity concerns for three ERC protocols with different lateral boundary guidelines (i.e., Goncharova, Dickerson, Stoub, & deToledo-Morrell, 2001; Honeycutt et al., 1998; Insausti et al., 1998). We used three novice raters to assess inter-rater reliability on a subset of scans (216 total ERCs), with the entire dataset measured by one rater with strong intra-rater reliability on each technique (234 total ERCs). We found moderate to strong inter-rater reliability for two techniques with consistent ERC lateral boundary endpoints (Goncharova, Honeycutt), with negligible to moderate reliability for the technique requiring consideration of collateral sulcal depth (Insausti). Left ERC and story memory associations were moderate and positive for two techniques designed to exclude the perirhinal cortex (Insausti, Goncharova), with the Insausti technique continuing to explain 10% of memory score variance after additionally controlling for depression symptom severity. Right ERC-story memory associations were nonexistent after excluding an outlier. Researchers are encouraged to consider challenges of rater training for ERC techniques and how lateral boundary endpoints may impact structure-function associations.
dc.language eng
dc.language.iso en_US
dc.relation.ispartof J Int Neuropsychol Soc
dc.relation.isversionof 10.1017/S135561771000072X
dc.subject Aged
dc.subject Brain Mapping
dc.subject Entorhinal Cortex
dc.subject Female
dc.subject Functional Laterality
dc.subject Geriatric Assessment
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Memory Disorders
dc.subject Middle Aged
dc.subject Neuropsychological Tests
dc.subject Reproducibility of Results
dc.title Entorhinal cortex volume in older adults: reliability and validity considerations for three published measurement protocols.
dc.title.alternative
dc.type Journal article
dc.description.version Version of Record
duke.date.pubdate 2010-9-0
duke.description.issue 5
duke.description.volume 16
dc.relation.journal Journal of the International Neuropsychological Society
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20937164
pubs.begin-page 846
pubs.end-page 855
pubs.issue 5
pubs.organisational-group Duke
pubs.organisational-group Faculty
pubs.publication-status Published
pubs.volume 16
dc.identifier.eissn 1469-7661


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