Browsing Duke Dissertations by Submit Date
Now showing items 21-40 of 5648
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Novel AAV Based Genome Editing Therapies for Glycogen Storage Disease Type Ia
(2023)Glycogen storage disease type Ia (GSD Ia) is an autosomal recessive metabolicdisorder caused deficiency of glucose-6-phosphatase (G6Pase) resulting from pathogenic variants in the G6PC gene. G6Pase catalyzes the hydrolysis ... -
On Impact of Network Architecture for Deep Learning
(2023)The architecture of neural networks is a crucial factor in the success of deep learning models across a range of fields, including computer vision and natural language processing (NLP). Specific architectures are tailored ... -
Adolescent Friendship Stability
(2023)Adolescence is a key point in the life course, and friendships during this time are strong predictors of health and behavioral outcomes. This dissertation seeks to understand the causes and consequences of friendship stability, ... -
Weak Lensing Cosmology Analysis with Stage-III Cosmic Shear Surveys
(2023)As light travels from distant galaxies it is coherently bent by the gravitational potential of the mass distribution between the source and the observer. This weak gravitational lensing creates correlations between galaxy ... -
Mathematical Analysis of High-Dimensional Algorithms and Models
(2023)High-dimensional data and problems are ubiquitous in recent research in scientific computing, machine learning, and their applications. Although many algorithms and models have been proposed and examined as efficient in ... -
DGA maps Induced by Decomposable Fillings with Z-coefficients
(2023)To every Legendrian link in R3, we can assign a differential graded algebra (DGA) called the Chekanov-Eliashberg DGA. An exact Lagrangian cobordism between two Legendrian links induces a DGA map between the corresponding ... -
Development and Validation of Software for Modeling Vagus Nerve Stimulation Across Species
(2023)Electrical stimulation and block of peripheral nerves hold great promise for treatment of a range of disease and disorders, but promising results from preclinical studies often fail to translate to successful clinical therapies. ... -
Elucidation of the Role(s) of Estrogens in Regulating Natural Killer Cell Biology in Breast Cancer Metastasis
(2023)Breast cancer is the most diagnosed cancer and the leading cause of cancer-related deaths among women worldwide. Estrogens, acting through their cognate receptor(s) support the growth of most breast cancers and as such, ... -
Essays on Firm Behavior
(2023)This dissertation studies three questions in which economic behavior at the firm level plays an important role. Chapter 2 studies how individual owner-managers shape firm conduct in the labor market. I use survey ... -
Cosmology Using Photometric Samples of Type Ia Supernovae: The First Joint Photometric Light Curve Analysis
(2023)Over the last twenty five years, type Ia supernova (SNIa) have been a crucial cosmological probe, responsible for the discovery of the accelerating expansion of the universe. But with the dawn of the next generation of telescopes ... -
Crisis: Masculinity and an Ethic of Care in American Literature
(2023)This dissertation takes three crisis periods that have occurred throughout American history—times of war, times of disease, and times of apocalypse—and examines how such periods simultaneously provoke what can be called ... -
Separate but “Equitable”: Colorblind Progressivism and Resegregation in Austin Schools
(2023)In 1954, the U.S. Supreme Court ruled in Brown v. Board of Education that segregated schools were inherently unequal and detrimental to students’ educational experiences. Just three decades later, school boards and communities ... -
The Low-Energy Charged-Current Electron Neutrino Cross Section on Argon at the Spallation Neutron Source
(2023)When a massive star reaches the end of its life, it releases 99\% of its energy in the form of neutrinos during a process known as a core-collapse supernova burst. The neutrinos are released in a prompt burst lasting several ... -
Nobilette, for orchestra, Rouge, for chamber ensemble and electronics, and "On Simplicity in Music"
(2023)The dissertation consists of an original musical composition, Nobilette, for orchestra, an original musical composition, Rouge, for chamber ensemble and electronics, and an essay, “On Simplicity in Music.” The essay examines ... -
From Labeled to Unlabeled Data: Understand Deep Visual Representations under Causal Lens
(2023)Deep vision models have been highly successful in various computer vision applications such as image classification, segmentation, and object detection. These models encode visual data into low-dimensional representations, ... -
Denoise high dimensional dataset with complicated noise and its clinical applications
(2023)We present a novel algorithm, called eOptShrink, for denoising matrices in the presence of high-dimensional, colored, and dependent noise with a separable covariance structure. Our approach is data-driven and does not require ... -
Exposomic modeling approaches for social and environmental determinants of health
(2023)Studies of human health have recently expanded to focus on the exposome paradigm, encompassing allexposures humans encounter from conception onward. The central theme of this work is to develop and test novel statistical ... -
Digital Health for Diabetes Self-Management Among Black Men: Barriers, Facilitators, and User Preferences
(2023)This dissertation aimed to explore the barriers, facilitators, and user preferences of digital health use for diabetes self-management among Black men while also investigating clinicians’ perspectives of digital health use ... -
Improving Scalability of Trapped-Ion Quantum Computers Using Gate-Level Techniques
(2023)Trapped ions provide a promising platform to build a practical quantum computer. Scaling the high performance of small systems to longer ion chains is a technical endeavor that benefits from both better hardware system design ... -
Ribosomal Biogenesis and Endomembrane Expansion Precede Cell Invasion
(2023)Cell invasion through basement membrane (BM) barriers is necessary for development and homeostasis, and is misappropriated in diseases like cancer. Many regulators of this complex biological process have been identified ...
