Browsing Duke Dissertations by Submit Date
Now showing items 1-20 of 3830
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Copper-Catalyzed Amino Oxygenation of Alkenes and Dienes: A Novel Amino-Initiation Pathway Using O-Benzoylhydroxylamines
(2018)Nitrogen-containing compounds, specifically the 1,2-oxyamino moiety, are of vital importance to modern pharmaceuticals, natural products, and agrochemicals. 1,2-Difunctionalization of alkenes offers an efficient approach ... -
Synthesis of Protected Amines from Azadiene and Azaallyl Anion Building Blocks
(2018)Amines are ubiquitous in medicinal compounds and essential to human health. We have addressed the limitations of amine synthesis by significantly expanding the utility of 2-azaallyl anions and 2-azaallyl anion-like reagents ... -
SINGLE-CHANNEL REAL-TIME DROWSINESS DETECTION BASED ON ELECTROENCEPHALOGRAPHY
(2018)Drowsiness is considered as a major risk factor in workplace injuries and fatalities as much as alcohol. Drowsiness-related accidents tend to be catastrophic. The need of a reliable drowsiness detection system is arising ... -
Spectroscopic differentiation and microscopic mapping of various materials using optical pump-probe contrast
(2018)Understanding the photophysical properties of materials is important in order to identify them, predict structural and functional changes, and improve fabrication methods. Here I demonstrate the use of time-resolved nonlinear ... -
An Induced Pluripotent Stem Cell-derived Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome for Disease Modeling and Drug Testing
(2018)Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary causes of death are stroke and cardiovascular ... -
Multi-stage Aeromechanical Phenomena and Computation Principles of a Compressor
(2018)This dissertation presents an investigation of the complex aeromechanical phenomena in a multi-stage turbomachinery. As a major component of the inter-disciplinary design, aeromechanical study demonstrates the interaction ... -
Evaluating Air Pollutant Exposure and the Impacts of Indoor Air Filtration Using Low-Cost Monitors
(2020)In highly polluted cities, many residents seek to reduce their personal exposure to air pollutants. However, over the course of a day, people spend time in a variety of micro-environments (e.g., different rooms in their ... -
Modernist Form: On the Problem of Fragmentation
(2018)This dissertation explores formal fragmentation in the modernist novel. It shows that such fragmentation not only represents the historical conditions of modernism, but also posits the potential for new forms of human relation. ... -
Approximate Inference for High-Dimensional Latent Variable Models
(2018)Latent variable models are widely used in applications ranging fromnatural language processing to recommender systems. Exact inferenceusing maximum likelihood for these models is generally NP-hard, andcomputationally prohibitive ... -
Networked Devotion: Hindu Adoption of Digital Media
(2018)Digital media prevail, determine, and shape contemporary lives and experiences, serving as an all-encompassing cultural system. Shaping modes of production and reception, digital media’s publics are networked to the media’s ... -
Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
(2018)Optical coherence tomography (OCT) is a non-contact imaging modality that provides micron scale resolution of in-vivo tissue. Due to these characteristics, OCT is the clinical standard of care in ophthalmology for the diagnosis ... -
Emotion and Identity in the Transition to Parenthood
(2018)Though families come in all shapes and sizes, many people recognize the birth of their first child as the start of their new family. The transition to parenthood that expectant parents experience has important implications ... -
Inheriting the Yugoslav Century: Art, History, and Generation
(2018)The dissertation examines the work contemporary artists, curators, and scholars who have, in the last two decades, addressed urgent political and economic questions by revisiting the legacies of the Yugoslav twentieth century: ... -
The Development of Cancer Vaccines Targeting Neoantigens for the Treatment of Malignant Astrocytomas
(2018)Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Conventional therapies for GBM typically fail to provide lasting antitumor benefits, owing to their inability to specifically eliminate all malignant ... -
Trad Jazz: Pre-War Aurality in the Postmodern City
(2018)Through an anthropological study of a set of interrelated traditional (“trad”) jazz scenes in New York City and New Orleans, Louisiana, this dissertation argues that gentrification – a class concept coined in 1960’s sociology ... -
Social Organisms: Biology and British Fiction in the Nineteenth Century
(2018)My argument is that the rise of biology at the start of the nineteenth challenged the individualism of the Enlightenment, and that it fell to the novel to enable readers to reimagine themselves in light of the resulting ... -
Metabolic Regulation of Kelch-like Proteins Through O-glycosylation
(2018)O-GlcNAcylation is a reversible post-translational modification that decorates an O-linked ß-N-acetylglucosamine (O-GlcNAc) moiety onto the serine/threonine residues of target proteins. In mammals, this modification is regulated ... -
Works of Mercy: Literature, Compassion, and Devotion in Early Modern England
(2018)“Works of Mercy: Literature, Compassion, and Devotion in Early Modern England,” argues for the crucial role of literature in shaping, expanding, and contesting the limits of compassion in early seventeenth century England. ... -
Performance Modeling & Analysis of Hyperledger Fabric (Permissioned Blockchain Network)
(2019)A blockchain is an immutable record of transactions (called ledger ) between a distributed set of mutually untrusting peers. Although blockchain networks provide tremendous benefits, there are concerns about whether their ... -
Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
(2018)Through the action of pattern recognition receptors (PRRs) the vertebrate immune system is able to detect and respond to invading pathogens. PRRs bind conserved microbial components and subsequently initiate pro-inflammatory ...
