Browsing Duke Dissertations by Subject "H3K27me3"

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The role of H3.3K27M-induced gene repression in brainstem gliomagenesis

Cordero, Francisco Javier (2017)

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pediatric brainstem tumor recently found to contain high incidence of H3.3K27M mutations. These mutations reprogram the H3K27me3 epigenetic landscape of DIPG ...