Now showing items 1-10 of 18
Pharmacological targeting of the mitochondrial phosphatase PTPMT1.
(J Pharmacol Exp Ther, 2010-05)
The dual-specificity protein tyrosine phosphatases (PTPs) play integral roles in the regulation of cell signaling. There is a need for new tools to study these phosphatases, and the identification of inhibitors potentially ...
Bayesian Analysis of Latent Threshold Dynamic Models
(Journal of Business and Economic Statistics, 2013-04-01)
We discuss a general approach to dynamic sparsity modeling in multivariate time series analysis. Time-varying parameters are linked to latent processes that are thresholded to induce zero values adaptively, providing natural ...
Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity.
(Dev Cell, 2008-07)
The endoplasmic reticulum stress response, also known as the unfolded protein response (UPR), has been implicated in the normal physiology of immune defense and in several disorders, including diabetes, cancer, ...
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation.
(J Clin Invest, 2011-03)
Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and a cellular infiltrate dominated by eosinophils. Numerous epidemiological studies have related the exacerbation of allergic asthma with an ...
Optimized approach to decision fusion of heterogeneous data for breast cancer diagnosis.
(Med Phys, 2006-08)
As more diagnostic testing options become available to physicians, it becomes more difficult to combine various types of medical information together in order to optimize the overall diagnosis. To improve diagnostic performance, ...
Mechanisms of specificity in neuronal activity-regulated gene transcription.
(Prog Neurobiol, 2011-08)
The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary ...
Three-dimensional computer generated breast phantom based on empirical data
(MEDICAL IMAGING 2008: PHYSICS OF MEDICAL IMAGING, PTS 1-3, 2008)
Distinct functions of POT1 at telomeres.
(Mol Cell Biol, 2008-09)
The mammalian protein POT1 binds to telomeric single-stranded DNA (ssDNA), protecting chromosome ends from being detected as sites of DNA damage. POT1 is composed of an N-terminal ssDNA-binding domain and a C-terminal protein ...
Functional evolution of mammalian odorant receptors.
(PLoS Genet, 2012)
The mammalian odorant receptor (OR) repertoire is an attractive model to study evolution, because ORs have been subjected to rapid evolution between species, presumably caused by changes of the olfactory system to adapt ...
A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.
(PLoS One, 2012)
BACKGROUND: Scythe/BAT3 is a member of the BAG protein family whose role in apoptosis has been extensively studied. However, since the developmental defects observed in Bat3-null mouse embryos cannot be explained solely ...