In a mouse model of ischemic stroke, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ...

Muscular dystrophy is a devastating disease for which no cures or preventative treatments are currently available. There has been great progress in the identification of genetic mutations that cause some forms of muscle ...

Hydrogen peroxide is used by animals and plants to deter the growth of microbial invaders by inflicting DNA lesions, protein oxidation and lipid membrane modifications. Pathogens protect themselves with enzymes and scavenging ...

The origin of man has motivated researchers to investigate differences between humans and our non-human relatives. The striking phenotypic differences that distinguish humans from chimpanzees are likely controlled by a ...

The disease process giving rise to cancer involves the consecutive accumulation of genetic or genomic alterations impacting the normal regulation of cellular functions. In cases of hereditary cancers, this process may be ...

Deciphering the molecular mechanisms driving the phenotypic differences between humans and primates remains a daunting challenge. Mutations found in protein coding DNA alone has not been able to explain these phenotypic ...

The relatively simple innate immune system of <italic>Caenorhabditis elegans</italic> and the number of traits that facilitate genetic and genomic analysis using this organism have nurtured rapid advances into the understanding ...

A blood draw is one of the most readily accessible, commonly practiced medical procedures with biomarker utility. In particular, transcriptome signatures of blood cells provide valuable insights into the developmental history ...

Gene regulatory networks (GRNs) provide a systems-level orchestration of an organism’s genome encoded anatomy. As biological networks are revealed, they continue to answer many questions including knowledge of how GRNs control ...

When a plant emerges from the soil, it faces a critical developmental transition from utilizing stored energy to grow rapidly toward the light, to developing chloroplasts and beginning photosynthesis. While it is known ...