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Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
(2017)
Biological systems are highly dynamic, yet our temporal resolution of suchdynamical
processes is often limited or difficult to test in the laboratory. The 24-hourcircadian
rhythm and the approximately 75-minute cell cycle ...
Functional Interrogation Of Anti-Cancer Drug Resistance
(2017)
Targeted therapeutics are among the most promising approaches for treating diverse
forms of malignancies. Indeed, as sequencing prices and technology continue to improve
it will be possible to achieve a precise map of each ...
Global Control of Cell-Cycle Transcription: Interplay Between CDK-APC/C and the Transcription Factor Network
(2017)
A periodic transcriptional program is a conserved feature of the eukaryotic cell cycle,
yet there have been contrasting views on whether it is predominantly controlled by
a CDK-APC/C network or a transcription factor (TF) ...
Genetic Constraints and the Evolution of Chemical Defenses in Multiple Tissues of Boechera stricta
(2017)
In order to deter herbivores, plants evolve defenses suited to different tissues and
varying patterns of herbivory. If the defense profiles of different tissues share
common genetic controls but differ in selective pressures, ...
Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences
(2018)
Telomeric sequences are often located internally on the chromosome in addition to
their usual positions at the ends of the chromosome. These internally-located telomeric
sequences have been termed “interstitial telomeric ...
The Glucocorticoid-Mediated Dynamics of Genome Architecture
(2018)
Human cells are perpetually receiving and responding to a variety of intrinsic and
extrinsic signals. A primary mechanism by which cells carry out these responses is
via changes in the regulation of gene expression. Many ...
Developmental Regulation in Response to Nutritional Status in Caenorhabditis elegans
(2019)
Developmental physiology is very sensitive to nutrient availability. For instance,
in the nematode C. elegans, newly hatched L1-stage larvae require food to initiate
postembryonic development. Despite the essential role ...
How Linkage Disequilibrium and Recombination Shape Genetic Variation Within and Between Species
(2019)
Meiotic recombination creates genetic diversity by shuffling combinations of alleles
across loci, yet alleles at neighboring loci often remain non-randomly associated.
This non-random association is known as linkage-dise...
Post-transcriptional regulation of gene expression in response to iron deficiency in Saccharomyces cerevisiae
(2010)
The ability of iron (Fe) to easily transition between two valence states makes it
a preferred co-factor for innumerable biochemical reactions, ranging from cellular
energy production, to oxygen transport, to DNA synthesis ...
Gene Duplication and the Evolution of Silenced Chromatin in Yeasts
(2010)
In <italic>Saccharomyces cerevisiae</italic>, proper maintenance of haploid cell identity
requires the SIR complex to mediate the silenced chromatin found at the cryptic mating-type
loci, <italic>HML</italic> and ...