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Global Control of Cell-Cycle Transcription: Interplay Between CDK-APC/C and the Transcription Factor Network
(2017)
A periodic transcriptional program is a conserved feature of the eukaryotic cell cycle,
yet there have been contrasting views on whether it is predominantly controlled by
a CDK-APC/C network or a transcription factor (TF) ...
Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
(2017)
Every cell in our body contains the same genetic material, but what differentiates
one cell type from another is the way in which that material is interpreted. Hidden
in the 98% of non-coding DNA sequences, once referred ...
The C. trachomatis effector protein TepP hijacks host cell signaling pathways to promote bacterial survival during infection.
(2017)
Chlamydia trachomatis is a bacterial pathogen with a large socioeconomic impact: it
is the leading cause of preventable blindness worldwide, and the most prevalent sexually
transmitted infection in the United States. Despite ...
Identifying Molecular Mechanisms of beta-arrestin Biased G Protein-Coupled Receptor Signaling
(2017)
G protein-coupled receptors (GPCRs) represent the largest and the most versatile family
of cell surface receptors. Members of this receptor family translate diverse extracellular
cues to intracellular responses, and are ...
Biased Signaling at the β2-adrenergic Receptor is established by Receptor-Transducer Interactions
(2018)
β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions
and belong to a large family of membrane proteins, termed as G-protein coupled receptors
(GPCRs). β-blockers (βAR antagonists) and ...
The Role of SIRT5 and Protein Succinylation in Regulating Cardiac Function and Metabolism
(2017)
Sirtuin 5 (SIRT5) is one of three mitochondrial proteins that belongs to the sirtuin
family of NAD+-dependent deacylases. Mitochondrial sirtuins (SIRT3-5) control metabolism
in physiological and pathophysiological conditions ...
Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis
(2017)
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling
cells undergo multiple rounds of genome duplication without an intervening mitosis.
Endocycling is known to lead to alterations ...
Mechanisms for Inactivation in Piezo Ion Channels
(2017)
An organism’s ability to sense mechanical forces is critical for the detection of
environmental stimuli as well as the regulation of internal processes necessary for
survival. In vertebrates, the molecular mechanisms of ...
Integrative Analysis of the Genomics of the Human Glucocorticoid Response
(2017)
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism,
and do so primarily by activating the transcription factor glucocorticoid receptor
(GR). Once activated, GR binds to thousands ...
A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
(2018)
The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization
of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at
a part of the cell cortex that becomes the ...