A periodic transcriptional program is a conserved feature of the eukaryotic cell cycle, yet there have been contrasting views on whether it is predominantly controlled by a CDK-APC/C network or a transcription factor (TF) ...

Every cell in our body contains the same genetic material, but what differentiates one cell type from another is the way in which that material is interpreted. Hidden in the 98% of non-coding DNA sequences, once referred ...

Chlamydia trachomatis is a bacterial pathogen with a large socioeconomic impact: it is the leading cause of preventable blindness worldwide, and the most prevalent sexually transmitted infection in the United States. Despite ...

G protein-coupled receptors (GPCRs) represent the largest and the most versatile family of cell surface receptors. Members of this receptor family translate diverse extracellular cues to intracellular responses, and are ...

β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions and belong to a large family of membrane proteins, termed as G-protein coupled receptors (GPCRs). β-blockers (βAR antagonists) and ...

Sirtuin 5 (SIRT5) is one of three mitochondrial proteins that belongs to the sirtuin family of NAD+-dependent deacylases. Mitochondrial sirtuins (SIRT3-5) control metabolism in physiological and pathophysiological conditions ...

Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...

An organism’s ability to sense mechanical forces is critical for the detection of environmental stimuli as well as the regulation of internal processes necessary for survival. In vertebrates, the molecular mechanisms of ...

Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism, and do so primarily by activating the transcription factor glucocorticoid receptor (GR). Once activated, GR binds to thousands ...

The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ...