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Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and is the leading cause of preventable blindness worldwide. Chlamydia is particularly intriguing from the perspective of cell biology because ...
Chromatin Accessibility Dynamics Underlying Development and Disease
Despite a largely static DNA sequence, our genomes are incredibly malleable. Comparative studies of chromatin features between different cell types, tissues, and species have revealed tremendous differences in how the genome ...
Mechanisms of Bacterial Expulsion as a Cell Autonomous Defense Strategy In the Bladder Epithelium
Due to its close proximity to the gastrointestinal tract, the human urinary tract issubjected to constant barrage by gut-associated bacteria. However, for the most part, this tract has resisted infection by various microbes. ...
Mechanisms by Which Guanylate Binding Proteins Target Pathogen Vacuoles and Promote Caspase-11 Dependent Pyroptosis
Guanylate binding proteins (Gbps) are a family of large GTPases that are highly stimulated by IFNγ and confer resistance to various viral, protozoan, and bacterial pathogens. Following infections of intracellular pathogens, ...