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Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences
(2018)
Telomeric sequences are often located internally on the chromosome in addition to
their usual positions at the ends of the chromosome. These internally-located telomeric
sequences have been termed “interstitial telomeric ...
The Glucocorticoid-Mediated Dynamics of Genome Architecture
(2018)
Human cells are perpetually receiving and responding to a variety of intrinsic and
extrinsic signals. A primary mechanism by which cells carry out these responses is
via changes in the regulation of gene expression. Many ...
Using Genomic Tools to Understand Speciation Dynamics in Madagascar's Mouse Lemurs (Order: Primates)
(2019)
Mouse lemurs (genus Microcebus; Order Primates) are endemic to the island nation of
Madagascar. These small, nocturnal primates offer a unique mammalian system ideally
suited to study the patterns and processes of speciation, ...
Topoisomerase 1-dependent Mutagenesis in Saccharomyces cerevisiae
(2015)
Topoisomerase 1 (Top1) resolves transcription-associated supercoils by generating
transient single-strand breaks in DNA and is a major source of transcription-associated
mutagenesis in Saccharomyces cerevisiae. Top1 generates ...
The role of H3.3K27M-induced gene repression in brainstem gliomagenesis
(2017)
Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pediatric brainstem
tumor recently found to contain high incidence of H3.3K27M mutations. These mutations
reprogram the H3K27me3 epigenetic landscape of DIPG ...
Large-scale Effectors of Gene Expression and New Models of Cell Division in the Haloarchaea.
(2015)
Like most Archaea, the hypersaline-adapted organism Halobacterium salinarum exhibits
characteristics from all three domains of life, including a eukaryotic histone protein,
a universal propensity to genetic rearrangements, ...
Genetic Analysis of Mitotic Recombination in Saccharomyces cerevisiae
(2016)
Mitotic genome instability can occur during the repair of double-strand breaks (DSBs)
in DNA, which arise from endogenous and exogenous sources. Studying the mechanisms
of DNA repair in the budding yeast, Saccharomyces cerevisiae ...
Quantifying Eukaryotic Gene Regulation in Hormone Response and Disease.
(2016)
Quantifying the function of mammalian enhancers at the genome or population scale
has been longstanding challenge in the field of gene regulation. Studies of individual
enhancers have provided anecdotal evidence on which ...
The Role of TET Proteins in the Epigenetic Regulation of Neural Gene Expression and Behavior
(2016)
Understanding how genes affect behavior is critical to develop precise therapies for
human behavioral disorders. The ability to investigate the relationship between genes
and behavior has been greatly advanced over the last ...
Investigatiing the Role of the Wild-Type Ras Isoforms in KRas-driven Cancer
(2015)
The RAS family is a group of small GTPases that can become constitutively activated
by point mutations that are found in about 30% of all cancer patients. There are
three well-characterized RAS family members: HRAS, NRAS, ...