Now showing items 1-5 of 5
Large-scale Effectors of Gene Expression and New Models of Cell Division in the Haloarchaea.
Like most Archaea, the hypersaline-adapted organism Halobacterium salinarum exhibits characteristics from all three domains of life, including a eukaryotic histone protein, a universal propensity to genetic rearrangements, ...
Mechanisms of Protein Localization in Cryptococcus neoformans Mediate Virulence and Immune Recognition
Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant disease and death in immunocompromised populations, in particular among those with advanced HIV infection. This fungus is found ubiquitously ...
Involvement of a DNA Polymerase III Subunit in the Bacterial Response to Quinolones
Quinolone treatment induces stabilized cleavage complexes (SCCs), consisting of a covalent gyrase-DNA complex, and processing of these complexes is thought to cause double-strand breaks and chromosome fragmentation. SCCs ...
Responses to Antifungal and Alkaline pH Stress in Human Fungal Pathogens
The fungal pathogens encounter ever-changing conditions during their pathogenic life cycles, including shifts from the environment to the human host. Fungi have evolved many pathways that allow them to overcome and even ...
Chemical and Genetic Modulation of the Host Immune Response to Mycobacterial Infection
Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis, which kills more people worldwide than any other infectious disease. In 2017, nearly 2 million people died of tuberculosis. Despite the ...