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Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...
Integrative Analysis of the Genomics of the Human Glucocorticoid Response
Glucocorticoids (GCs) are potent steroid hormones that regulate immunity and metabolism, and do so primarily by activating the transcription factor glucocorticoid receptor (GR). Once activated, GR binds to thousands ...
The Discovery of EJC Independent Roles for EIF4A3 in Mitosis, Microtubules, and Neural Crest Development
The exon junction complex (EJC) is comprised of three core components: MAGOH, RBM8A, and EIF4A3. The EJC is canonically known to regulate many aspects of RNA metabolism as well as function in mitosis. Previous work on the ...