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Genetic Analysis of Mitotic Recombination in Saccharomyces cerevisiae
Mitotic genome instability can occur during the repair of double-strand breaks (DSBs) in DNA, which arise from endogenous and exogenous sources. Studying the mechanisms of DNA repair in the budding yeast, Saccharomyces cerevisiae ...
Mechanisms of Chlamydia manipulation of host cell biology revealed through genetic approaches
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and is the leading cause of preventable blindness worldwide. Chlamydia is particularly intriguing from the perspective of cell biology because ...
Genomic and Epigenomic Attributes of Alpha Satellite Underlying Function Within the Human Centromere Region
The centromere serves as the foundation for the kinetochore and attachment point for spindle microtubules during metaphase. The proper function of this locus is required to ensure chromosome segregation and genomic stability. ...