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Regulation of Chromosome Structure During Both of the Endocycle and Mitosis is Critical for Accurate Chromosome Segregation in Polypoid Mitosis
Polyploid cells are generated through a cell cycle variant termed the endocycle. Endocycling cells undergo multiple rounds of genome duplication without an intervening mitosis. Endocycling is known to lead to alterations ...
Identifying Novel Cardiomyopathy Genes Using Drosophila melanogaster
Traditional <italic>Drosophila</italic> hearts screens have focused on early patterning and development, and adult heart phenotypes have only recently been pursued due to difficulty in accurately measuring cardiac function ...
Genetic Dissection of the Biological and Molecular Role of IDH1 Mutations in Glioma
Gliomas are tumors of the central nervous system for which improvements in treatment are critically needed. Mutations in IDH1 and IDH2, which encode the cytosolic and mitochondrial NADP+-dependent isocitrate dehydrogenases, ...
Understanding the Organization, Location, and Interactions of Actin-based Structures During Drosophila Dorsal Closure
Epithelial sheet morphogenesis is characterized by dynamic tissue movements, resulting in the recognition and adhesion of cells to generate a seamless epithelium. Each step is mediated by carefully organized, cellular actin ...