Now showing items 201-205 of 205
Concentration-dependent recruitment of mammalian odorant receptors
Deciphering natural odor plumes with dynamic changes in odor concentrations presents a common challenge to all animals. A fundamental challenge in studying the organization principles of the olfactory system to encode odor ...
Genome Engineering in Stem Cells for Skeletal Muscle Regeneration
Skeletal muscle has the innate ability to robustly regenerate in a highly orchestrated fashion that is initiated by satellite cells, the resident stem cell population. These cells are defined by their uniform expression ...
Identifying the Connection between the Cell Surface and pH-Sensing in a Human Fungal Pathogen
Stress tolerance and adaptability to dynamic environments are two things that make a microbial pathogen especially dangerous in the setting of a human infection. Cryptococcus neoformans, a ubiquitous pathogenic fungus, is ...
Responses to Antifungal and Alkaline pH Stress in Human Fungal Pathogens
The fungal pathogens encounter ever-changing conditions during their pathogenic life cycles, including shifts from the environment to the human host. Fungi have evolved many pathways that allow them to overcome and even ...
Homologous Recombination Outcomes of Double-Strand Break- initiated Events in Saccharomyces cerevisiae
Homologous recombination (HR) is responsible for repairing otherwise lethal DNA double-strand breaks (DSBs) using a homologous donor template. The work in this dissertation, using the budding yeast Saccharomyces cerevisiae ...