Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
Search 
  •   DukeSpace
  • Theses and Dissertations
  • Duke Dissertations
  • Search
  •   DukeSpace
  • Theses and Dissertations
  • Duke Dissertations
  • Search
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search

Show Advanced FiltersHide Advanced Filters

Filters

Use filters to refine the search results.

Now showing items 1-10 of 16

  • Sort Options:
  • Relevance
  • Title Asc
  • Title Desc
  • Issue Date Asc
  • Issue Date Desc
  • Results Per Page:
  • 5
  • 10
  • 20
  • 40
  • 60
  • 80
  • 100
Thumbnail

Structural and Dynamic Studies of RNA Bulge Motifs Utilizing Nuclear Magnetic Resonance 

Merriman, Dawn Kellogg (2018)
Bulges are ubiquitous building blocks of the three-dimensional structure of RNA. They help define the global structure of helices and points of flexibility allowing for functionally important dynamics, such as binding of ...
Thumbnail

Biased Signaling at the β2-adrenergic Receptor is established by Receptor-Transducer Interactions 

Choi, Minjung (2018)
β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions and belong to a large family of membrane proteins, termed as G-protein coupled receptors (GPCRs). β-blockers (βAR antagonists) and ...
Thumbnail

Role of O-GlcNAc in the Vertebrate Secretory Pathway 

Cox, Nathan James (2018)
O-linked β-N-acetylglucosamine (O-GlcNAc) exerts myriad effects on protein localization, activation, inhibition, stability, conformational changes, or degradation. However, the biochemical effects of O-GlcNAc on the vast ...
Thumbnail

Dynamic Control of Metabolism for Renewable Production of Valuable Chemicals and Novel Biomaterials 

Cooper, Charles Bridwell (2018)
Increasing concerns over the environmental impact and long-term sustainability of human economic activity has motivated a search for less resource-intensive methods for the manufacture of chemicals and generation of energy. ...
Thumbnail

Towards Guiding Principles for Targeting RNA: Rational Approaches to Design and Synthesize RNA-Biased Small Molecule Libraries 

Morgan, Brittany Suzanne (2018)
RNA is increasingly recognized as a therapeutic target in many diseases, including viral and bacterial infections, neurodegenerative disease, and cancer. Despite this, no FDA-approved drugs target RNA, aside from select ...
Thumbnail

Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging 

Yuan, Lifeng (2018)
Cellular senescence is a fundamental cell fate playing significant and complex roles during tumorigenesis and natural aging process. However, the molecular determinants distinguishing senescence from other temporary and ...
Thumbnail

O-GlcNAc-Mediated Protein-Protein Interactions in Cell Signaling 

Tarbet, Heather Jean (2018)
Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential signaling mechanism that affects diverse processes such as cell cycle, metabolism, and death. Aberrant signaling has been implicated in numerous ...
Thumbnail

Development of pattern recognition technique for classification of RNA secondary structures by small molecules 

Eubanks, Christopher (2018)
Three-dimensional RNA structures are notoriously difficult to determine, and the link between secondary structure and RNA conformation is only beginning to be understood. In this dissertation, I will discuss the development ...
Thumbnail

New Insights into GPCR–Transducer Coupling 

Cahill, Thomas J. (2018)
β-arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis.  Using a panel of GPCRs believed to couple differently ...
Thumbnail

Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design 

Ojewole, Adegoke (2018)
Proteins are essential for myriad biological functions, including DNA replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely ...
  • 1
  • 2

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Discover

AuthorBae, Junu Tyle (1)Cahill, Thomas J. (1)CHEN, PO-HAN (1)Choi, Minjung (1)Cooper, Charles Bridwell (1)Cox, Nathan James (1)Eubanks, Amber Leigh (1)Eubanks, Christopher (1)Kuk, Alvin Chun Yin (1)Merriman, Dawn Kellogg (1)... View MoreDate Issued
2018 (16)
Type
Dissertation (16)
Subject
Biochemistry (16)
Cellular biology (4)Chemistry (4)Molecular biology (4)O-GlcNAc (3)Biophysics (2)Chemical Biology (2)Organic chemistry (2)Pharmacology (2)2-Oxazolidinone (1)... View MoreDepartmentChemistry (7)Biochemistry (5)Computational Biology and Bioinformatics (1)Molecular Cancer Biology (1)Molecular Genetics and Microbiology (1)Pharmacology (1)
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Support the Libraries
Duke University