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Structural and Dynamic Studies of RNA Bulge Motifs Utilizing Nuclear Magnetic Resonance
(2018)
Bulges are ubiquitous building blocks of the three-dimensional structure of RNA. They
help define the global structure of helices and points of flexibility allowing for
functionally important dynamics, such as binding of ...
Biased Signaling at the β2-adrenergic Receptor is established by Receptor-Transducer Interactions
(2018)
β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions
and belong to a large family of membrane proteins, termed as G-protein coupled receptors
(GPCRs). β-blockers (βAR antagonists) and ...
Role of O-GlcNAc in the Vertebrate Secretory Pathway
(2018)
O-linked β-N-acetylglucosamine (O-GlcNAc) exerts myriad effects on protein localization,
activation, inhibition, stability, conformational changes, or degradation. However,
the biochemical effects of O-GlcNAc on the vast ...
Dynamic Control of Metabolism for Renewable Production of Valuable Chemicals and Novel Biomaterials
(2018)
Increasing concerns over the environmental impact and long-term sustainability of
human economic activity has motivated a search for less resource-intensive methods
for the manufacture of chemicals and generation of energy. ...
Towards Guiding Principles for Targeting RNA: Rational Approaches to Design and Synthesize RNA-Biased Small Molecule Libraries
(2018)
RNA is increasingly recognized as a therapeutic target in many diseases, including
viral and bacterial infections, neurodegenerative disease, and cancer. Despite this,
no FDA-approved drugs target RNA, aside from select ...
Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging
(2018)
Cellular senescence is a fundamental cell fate playing significant and complex roles
during tumorigenesis and natural aging process. However, the molecular determinants
distinguishing senescence from other temporary and ...
O-GlcNAc-Mediated Protein-Protein Interactions in Cell Signaling
(2018)
Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential
signaling mechanism that affects diverse processes such as cell cycle, metabolism,
and death. Aberrant signaling has been implicated in numerous ...
Development of pattern recognition technique for classification of RNA secondary structures by small molecules
(2018)
Three-dimensional RNA structures are notoriously difficult to determine, and the link
between secondary structure and RNA conformation is only beginning to be understood.
In this dissertation, I will discuss the development ...
New Insights into GPCR–Transducer Coupling
(2018)
β-arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize
G protein signaling, initiate signaling on their own, and mediate receptor endocytosis.
Using a panel of GPCRs believed to couple differently ...
Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
(2018)
Proteins are essential for myriad biological functions, including DNA replication,
molecular transport, catalysis, and antigen recognition. Protein function is determined
by three dimensional structure, which is largely ...