Bulges are ubiquitous building blocks of the three-dimensional structure of RNA. They help define the global structure of helices and points of flexibility allowing for functionally important dynamics, such as binding of ...

β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions and belong to a large family of membrane proteins, termed as G-protein coupled receptors (GPCRs). β-blockers (βAR antagonists) and ...

O-linked β-N-acetylglucosamine (O-GlcNAc) exerts myriad effects on protein localization, activation, inhibition, stability, conformational changes, or degradation. However, the biochemical effects of O-GlcNAc on the vast ...

Increasing concerns over the environmental impact and long-term sustainability of human economic activity has motivated a search for less resource-intensive methods for the manufacture of chemicals and generation of energy. ...

RNA is increasingly recognized as a therapeutic target in many diseases, including viral and bacterial infections, neurodegenerative disease, and cancer. Despite this, no FDA-approved drugs target RNA, aside from select ...

Cellular senescence is a fundamental cell fate playing significant and complex roles during tumorigenesis and natural aging process. However, the molecular determinants distinguishing senescence from other temporary and ...

Protein modification by O-linked β-N-acetylglucosamine (O-GlcNAc) is an essential signaling mechanism that affects diverse processes such as cell cycle, metabolism, and death. Aberrant signaling has been implicated in numerous ...

O-GlcNAcylation is a reversible post-translational modification that decorates an O-linked ß-N-acetylglucosamine (O-GlcNAc) moiety onto the serine/threonine residues of target proteins. In mammals, this modification is regulated ...

Plasmodium is the causal agent of malaria, which is a parasitic disease that affects more than 215 million people annually and is endemic in 91 countries worldwide. Unfortunately, the parasites have developed resistance ...

Proteins are essential for myriad biological functions, including DNA replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely ...