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    Envelope-specific IgG Responses in HIV-infected Women 

    Martinez, David Rafael (2018)
    A better understanding of 1) maternal HIV Envelope (Env)-specific IgG responses that are partially protective against vertical HIV transmission, and 2) factors that mediate the transplacental transfer of maternal protective ...
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    Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma 

    Davis, Nicholas Samuel (2018)
    Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma and a leading cause of death among B cell lymphomas. The disease displays a remarkable amount of genetic and clinical heterogeneity, ...
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    Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design 

    Nelson, Cody Shaw (2018)
    Human cytomegalovirus (HCMV) is the most common cause of congenital infection worldwide, impacting 1 in 150 live-born infants. Children afflicted by congenital HCMV frequently suffer from lifelong, debilitating neurologic ...

    The Development of Cancer Vaccines Targeting Neoantigens for the Treatment of Malignant Astrocytomas 

    Swartz, Adam Michael (2018)
    Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Conventional therapies for GBM typically fail to provide lasting antitumor benefits, owing to their inability to specifically eliminate all malignant ...

    Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression 

    Chong, Meng-Yang (2018)
    Cellular senescence is a unique cell fate characterized by stable cell cycle arrest and the extensive production and secretion of various cytokines, chemokines, proteases, and growth factors, a phenomenon known ...

    The Development and Mechanisms of Protective Humoral Immunity to HIV 

    Wills, Saintedym (2018)
    A successful HIV-1 vaccine is likely to be comprised of a polyclonal response with multiple antiviral functions that generate both broadly neutralizing antibodies (bNAbs) that neutralize multiple strains of HIV and/ or functional ...

    The Role of Notch Signaling in Type-2 Immunity 

    Dell'Aringa, Mark (2018)
    Over 1.5 billion individuals are infected with intestinal helminths worldwide, with a majority of those infected living in developing nations. In developed nations intestinal helminth infections are very rare, while incidences ...

    Glutaminase Modulates T Cell Metabolism and Function in Inflammation and Cancer 

    Johnson, Marc O (2018)
    During the immune response, helper T cells must proliferate and upregulate key metabolic programs including glucose and glutamine uptake. Metabolic reprogramming is imperative for appropriate T cell responses, as inhibition ...

    Regulation and Derailment of an Innate-like T Cell Thymic Developmental Pathway 

    Roy, Sumedha (2018)
    Invariant Natural Killer T (iNKT) and γδNKT cells are well-characterized innate-like counterparts of αβ and γδ T cells respectively that express semi-invariant T cell receptors (TCRs) and are capable of mounting rapid immune ...

    Fc-Dependent Antibody-Mediated Functions Against HIV-1 

    Tay, Matthew Zirui (2018)
    Antibodies are important therapeutic agents that can be elicited by vaccination or directly infused. However, the mechanisms by which antibodies achieve protection against pathogens are not fully elucidated, in particular ...
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    AuthorArifuzzaman, Mohammad (1)Chen, Shiwei (1)Chong, Meng-Yang (1)Davis, Nicholas Samuel (1)Dell'Aringa, Mark (1)Finethy, Ryan Harold (1)Jaslow, Sarah Louise (1)Johnson, Marc O (1)Martinez, David Rafael (1)Nelson, Cody Shaw (1)... View MoreDate Issued
    2018 (16)
    Type
    Dissertation (16)
    Subject
    Immunology (16)
    Microbiology (7)Molecular biology (4)Virology (4)Cellular biology (3)Cancer (2)Genetics (2)HIV (2)Vaccine (2)Actin (1)... View MoreDepartmentMolecular Genetics and Microbiology (8)Immunology (4)Pharmacology (2)Genetics and Genomics (1)Pathology (1)