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Envelope-specific IgG Responses in HIV-infected Women
(2018)
A better understanding of 1) maternal HIV Envelope (Env)-specific IgG responses that
are partially protective against vertical HIV transmission, and 2) factors that mediate
the transplacental transfer of maternal protective ...
Functional Drivers of Therapeutic Response in Diffuse Large B Cell Lymphoma
(2018)
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma
and a leading cause of death among B cell lymphomas. The disease displays a remarkable
amount of genetic and clinical heterogeneity, ...
Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design
(2018)
Human cytomegalovirus (HCMV) is the most common cause of congenital infection worldwide,
impacting 1 in 150 live-born infants. Children afflicted by congenital HCMV frequently
suffer from lifelong, debilitating neurologic ...
The Development of Cancer Vaccines Targeting Neoantigens for the Treatment of Malignant Astrocytomas
(2018)
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Conventional
therapies for GBM typically fail to provide lasting antitumor benefits, owing to their
inability to specifically eliminate all malignant ...
Senescence Associated Secretory Phenotype Regulation in Lung Aging and Malignancy Progression
(2018)
Cellular senescence is a unique cell fate characterized by stable cell cycle arrest
and the extensive production and secretion of various cytokines, chemokines, proteases,
and growth factors, a phenomenon known ...
The Development and Mechanisms of Protective Humoral Immunity to HIV
(2018)
A successful HIV-1 vaccine is likely to be comprised of a polyclonal response with
multiple antiviral functions that generate both broadly neutralizing antibodies (bNAbs)
that neutralize multiple strains of HIV and/ or functional ...
The Role of Notch Signaling in Type-2 Immunity
(2018)
Over 1.5 billion individuals are infected with intestinal helminths worldwide, with
a majority of those infected living in developing nations. In developed nations intestinal
helminth infections are very rare, while incidences ...
Glutaminase Modulates T Cell Metabolism and Function in Inflammation and Cancer
(2018)
During the immune response, helper T cells must proliferate and upregulate key metabolic
programs including glucose and glutamine uptake. Metabolic reprogramming is imperative
for appropriate T cell responses, as inhibition ...
Regulation and Derailment of an Innate-like T Cell Thymic Developmental Pathway
(2018)
Invariant Natural Killer T (iNKT) and γδNKT cells are well-characterized innate-like
counterparts of αβ and γδ T cells respectively that express semi-invariant T cell
receptors (TCRs) and are capable of mounting rapid immune ...
Fc-Dependent Antibody-Mediated Functions Against HIV-1
(2018)
Antibodies are important therapeutic agents that can be elicited by vaccination or
directly infused. However, the mechanisms by which antibodies achieve protection against
pathogens are not fully elucidated, in particular ...