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Hybrid Sterility and Segregation Distortion in Drosophila pseudoobscura and Drosophila persimilis
Speciation has occurred countless times throughout history, and yet the genetic mechanisms that lead to speciation are still missing pieces. Here, we describe the genetics of two processes that can act alone or together ...
Identifying Novel Cardiomyopathy Genes Using Drosophila melanogaster
Traditional <italic>Drosophila</italic> hearts screens have focused on early patterning and development, and adult heart phenotypes have only recently been pursued due to difficulty in accurately measuring cardiac function ...
Genetic Analysis of the Contribution of Ion Channels to "Drosophila" Nociception
<p>Nociceptors are specialized primary sensory neurons that represent the first line of defense against potentially tissue damaging environmental stimuli, and are involved in pathological pain states caused by nerve damage, ...
Genetic Dissection of the Biological and Molecular Role of IDH1 Mutations in Glioma
Gliomas are tumors of the central nervous system for which improvements in treatment are critically needed. Mutations in IDH1 and IDH2, which encode the cytosolic and mitochondrial NADP+-dependent isocitrate dehydrogenases, ...