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A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.
(PLoS One, 2013)
Infiltration of myeloid cells in the tumor microenvironment is often associated with
enhanced angiogenesis and tumor progression, resulting in poor prognosis in many types
of cancer. The polypeptide chemokine PK2 (Bv8, PROK2) ...