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Epigenetic Regulation of Aicda Transcription in B Cells
(2012)
Activation-induced cytidine deaminase (AID), encoded by the Aicda gene, is indispensable
for secondary antibody diversification through somatic hypermutation (SHM) and class
switch recombination (CSR). It is expressed ...
Hybrid Sterility and Segregation Distortion in Drosophila pseudoobscura and Drosophila persimilis
(2012)
Speciation has occurred countless times throughout history, and yet the genetic mechanisms
that lead to speciation are still missing pieces. Here, we describe the genetics of
two processes that can act alone or together ...
Identifying Novel Cardiomyopathy Genes Using Drosophila melanogaster
(2012)
Traditional <italic>Drosophila</italic> hearts screens have focused on early patterning
and development, and adult heart phenotypes have only recently been pursued due to
difficulty in accurately measuring cardiac function ...
B-cyclin/CDK Regulation of Mitotic Spindle Assembly through Phosphorylation of Kinesin-5 Motors in the Budding Yeast, <italic>Saccharomyces cerevisiae</italic>
(2012)
Although it has been known for many years that B-cyclin/CDK complexes regulate the
assembly of the mitotic spindle and entry into mitosis, the full complement of relevant
CDK targets has not been identified. It has previously ...
The Role of Polyploidy in Phenotypic and Genomic Evolution in the Shy Monkeyflower, <i>Mimulus sookensis<i>
(2012)
In an ever-changing world, evolution is an essential process that may allow organisms
to adapt to their environment through natural selection. All evolutionary processes
act through a single fundamental medium: genetic variation. ...
Short-Range Inter-Blastomere Signaling Specifies Ectodermal Fate and is Required for Skeletal Patterning in the Sea Urchin
(2012)
Sea urchin larvae possess a beautiful, intricately patterned, calcium-carbonate skeleton.
Formation of this complex structure results from two independent processes within
the developing embryo: specification of the mesenchymal ...
Genetic Analysis of the Contribution of Ion Channels to "Drosophila" Nociception
(2012)
<p>Nociceptors are specialized primary sensory neurons that represent the first line
of defense against potentially tissue damaging environmental stimuli, and are involved
in pathological pain states caused by nerve damage, ...
Genetic and Environmental Constraints on Developmental Systems: Towards Predicting Genetic Responses to Climate Change in Sea Urchins
(2012)
Many factors, including gene networks, developmental processes, and the environment
mediate the link between the activity of genes and complex phenotypes in higher organisms.
While genetic variants are the raw material for ...
Genomic characterization and comparative analysis of the Xce candidate region
(2012)
Mechanisms of sex chromosome dosage compensation vary widely between different vertebrate
species. All eutherians, including humans, other primates, and rodents, undergo random
X chromosome inactivation in early female embryos, ...
MicroRNA Function in Cellular Stress Response
(2012)
MicroRNAs are key post-transcriptional regulators that have been found to play critical
roles in the regulation of cellular functions. There is an emerging concept that
microRNAs may be just as essential for fine-tuning ...