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Developmental Regulation of Injury-Induced Cell Cycles in the Drosophila Hindgut
(2020)
As development progresses, many tissues lose their ability to regenerate via cellular
proliferation. In some tissues, including the human heart and kidneys, injury activates
a non-proliferative cellular response known as ...
Estrogen’s Impact on the Specialized Transcriptome, Brain, and Vocal Learning Behavior of a Sexually Dimorphic Songbird
(2020)
The song system of the zebra finch (Taeniopygia guttata) is highly sexually dimorphic,
where only males develop the neural structures necessary to learn and produce learned
vocalizations in adulthood. During early development, ...
Developing Molecular Tools for Interrogating a Vocal Learning Avian Species
(2020)
The zebra finch, an Australian songbird, is a uniquely powerful model organism for
the study of vocal production learning, and its song system shares behavioral, anatomical,
and genetic properties with the human spoken language ...
Interrogating Chromatin Dynamics Surrounding a DNA Double-Strand Break and Ensuing Non-Homologous End-Joining Mediated Repair
(2020)
The DNA double-strand break (DSB) is one of the most toxic genomic lesions that can
occur in any living cell. Failure to repair DSBs results in cell cycle arrest and
ultimately programmed cell death, while improper repair ...
Multiple Testing Embedded in an Aggregation Tree With Applications to Omics Data
(2020)
In my dissertation, I have developed computational methods for high dimensional inference,
motivated by the analysis of omics data. This dissertation is divided into two parts.
The first part of this dissertation is motivated ...
Genome-wide Analyses of Recombination and the Genetic Architecture of Virulence Traits in Cryptococcus
(2020)
Fungi of the basidiomycete genus Cryptococcus cause disease in an estimated quarter
of a million people, annually. Cryptococcus neoformans and Cryptococcus deneoformans
are the two most prevalent disease causing species ...
Genome Engineering in Stem Cells for Skeletal Muscle Regeneration
(2020)
Skeletal muscle has the innate ability to robustly regenerate in a highly orchestrated
fashion that is initiated by satellite cells, the resident stem cell population. These
cells are defined by their uniform expression ...
Identifying the Connection between the Cell Surface and pH-Sensing in a Human Fungal Pathogen
(2020)
Stress tolerance and adaptability to dynamic environments are two things that make
a microbial pathogen especially dangerous in the setting of a human infection. Cryptococcus
neoformans, a ubiquitous pathogenic fungus, is ...
Homologous Recombination Outcomes of Double-Strand Break- initiated Events in Saccharomyces cerevisiae
(2020)
Homologous recombination (HR) is responsible for repairing otherwise lethal DNA double-strand
breaks (DSBs) using a homologous donor template. The work in this dissertation, using
the budding yeast Saccharomyces cerevisiae ...