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Next Gen sequencing tools to derive insights into protein expression and gene function
Human physiology is heavily influenced by the colonization of microbes in the gastrointestinal tract. A major roadblock to understanding this process is our inability to genetically manipulate new bacterial species ...
Epigenetic Regulation of Aicda Transcription in B Cells
Activation-induced cytidine deaminase (AID), encoded by the Aicda gene, is indispensable for secondary antibody diversification through somatic hypermutation (SHM) and class switch recombination (CSR). It is expressed ...
Genome Engineering Tools to Dissect Gene Regulation
Over the past several years genome and epigenome engineering has been propelled forward by CRISPR-Cas technologies. These prokaryotic defense systems work well in mammalian cells in a manner that is remarkably robust: they ...