Now showing items 1-4 of 4
Structural and Dynamic Studies of RNA Bulge Motifs Utilizing Nuclear Magnetic Resonance
Bulges are ubiquitous building blocks of the three-dimensional structure of RNA. They help define the global structure of helices and points of flexibility allowing for functionally important dynamics, such as binding of ...
Development of pattern recognition technique for classification of RNA secondary structures by small molecules
Three-dimensional RNA structures are notoriously difficult to determine, and the link between secondary structure and RNA conformation is only beginning to be understood. In this dissertation, I will discuss the development ...
Exploring Kinases of Metabolism and Signaling in the Malaria Parasite Plasmodium
Plasmodium is the causal agent of malaria, which is a parasitic disease that affects more than 215 million people annually and is endemic in 91 countries worldwide. Unfortunately, the parasites have developed resistance ...
Examination of Menaquinone Biosynthesis Genes in Chlamydia trachomatis
The obligated intracellular bacterium Chlamydia trachomatis is a pathogen of immense clinical and societal importance with over 1.5 million cases of new infection reported annually in the United States alone. With asymptomatic ...